ArticleBMC infectious diseases2011
The antimicrobial resistance patterns and associated determinants in Streptococcus suis isolated from humans in southern Vietnam, 1997-2008.
Article in BMC infectious diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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43 citing papers in PubMed, 75 citations in OpenAlex.
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- Epidemiology and genetic diversity of Streptococcus suis in smallhold swine farms in the Philippines.Scientific reports · 2023Article
- Genomic comparison of two Streptococcus suis serotype 1 strains recovered from porcine and human disease cases.Scientific reports · 2023Article
- Genomic characterization and virulence of Streptococcus suis serotype 4 clonal complex 94 recovered from human and swine samples.PloS one · 2023Article
- Virulence gene profile and antimicrobial resistance of non-typeable Streptococcus suis isolated from clinically healthy and diseased pigs from North East India.Folia microbiologica · 2022Article
- How Streptococcus suis escapes antibiotic treatments.Veterinary research · 2022Review
- HumanTropical medicine and infectious disease · 2022Review
- Genetic diversity and variation in antimicrobial-resistance determinants of non-serotype 2Microbial genomics · 2022Article
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- Antimicrobial Susceptibility ofAntibiotics (Basel, Switzerland) · 2022Article
- Characterization of integrative and conjugative elements carrying antibiotic resistance genes ofFrontiers in microbiology · 2022Article
- Non-Penicillin-SusceptiblePathogens (Basel, Switzerland) · 2021Article
- Large-scale genomic analysis of antimicrobial resistance in the zoonotic pathogen Streptococcus suis.BMC biology · 2021Article
- Update on the Mechanisms of Antibiotic Resistance and the Mobile Resistome in the Emerging Zoonotic PathogenMicroorganisms · 2021Review
- Anatomical Site, Typing, Virulence Gene Profiling, Antimicrobial Susceptibility and Resistance Genes ofAntibiotics (Basel, Switzerland) · 2021Article
- In vitro and In vivo Antibacterial Effects of Nisin Against Streptococcus suis.Probiotics and antimicrobial proteins · 2021Article
- Genomic Characterization ofFrontiers in microbiology · 2021Article
- Serotypes, Virulence-Associated Factors, and Antimicrobial Resistance ofFrontiers in veterinary science · 2021Article
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundStreptococcus suis is an emerging zoonotic pathogen and is the leading cause of bacterial meningitis in adults in Vietnam. Systematic data on the antimicrobial susceptibility profiles of S. suis strains isolated from human cases are lacking. We studied antimicrobial resistance and associated resistance determinants in S. suis isolated from patients with meningitis in southern Vietnam.
methodsS. suis strains isolated between 1997 and 2008 were investigated for their susceptibility to six antimicrobial agents. Strains were screened for the presence and expression of tetracycline and erythromycin resistance determinants and the association of tet(M) genes with Tn916- like transposons. The localization of tetracycline resistance gene tet(L) was determined by pulse field gel electrophoresis and Southern blotting.
resultsWe observed a significant increase in resistance to tetracycline and chloramphenicol, which was concurrent with an increase in multi-drug resistance. In tetracycline resistance strains, we identified tet(M), tet(O), tet(W) and tet(L) and confirmed their expression. All tet(M) genes were associated with a Tn916-like transposon. The co-expression of tet(L) and other tetracycline resistance gene(s) encoding for ribosomal protection protein(s) was only detected in strains with a minimum inhibitory concentration (MIC) of tetracycline of ≥ 64 mg/L.
conclusionsWe demonstrated that multi-drug resistance in S. suis causing disease in humans in southern Vietnam has increased over the 11-year period studied. We report the presence and expression of tet(L) in S. suis strains and our data suggest that co-expression of multiple genes encoding distinct mechanism is required for an MIC ≥ 64 mg/L to tetracycline.
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