ArticleInvestigative genetics2011
Analyses of a set of 128 ancestry informative single-nucleotide polymorphisms in a global set of 119 population samples.
Article in Investigative genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed.
- Review
- Forensic DNA phenotyping: a review on SNP panels, genotyping techniques, and prediction models.Forensic sciences research · 2025Review
- Genetic diversity of North African populations in the 17q21 genomic region.Mammalian genome : official journal of the International Mammalian Genome Society · 2024Article
- Mitochondrial DNA D-loop SNPs unveil molecular signatures of milk production variation in Murrah buffalo.Molecular biology reports · 2024Article
- Association ofmedRxiv : the preprint server for health sciences · 2023Article
- Forensic biogeographical ancestry inference: recent insights and current trends.Genes & genomics · 2023Review
- Reanalyzing the genetic history of Kra-Dai speakers from Thailand and new insights into their genetic interactions beyond Mainland Southeast Asia.Scientific reports · 2023Article
- Multivariate statistical approach and machine learning for the evaluation of biogeographical ancestry inference in the forensic field.Scientific reports · 2022Article
- Evaluation of the association of heterozygous germline variants in NTHL1 with breast cancer predisposition: an international multi-center study of 47,180 subjects.NPJ breast cancer · 2021Article
- Genetic profiles of 103,106 individuals in the Taiwan Biobank provide insights into the health and history of Han Chinese.NPJ genomic medicine · 2021Article
- Genetic ancestry plays a central role in population pharmacogenomics.Communications biology · 2021Article
- Article
- A high-resolution HLA imputation system for the Taiwanese population: a study of the Taiwan Biobank.The pharmacogenomics journal · 2020Article
- MI-MAAP: marker informativeness for multi-ancestry admixed populations.BMC bioinformatics · 2020Article
- Ancestry informative DIP loci for dissecting genetic structure and ancestry proportions of Qinghai Tibetan and Tibet Tibetan groups.Molecular biology reports · 2020Article
- Developing ancestry informative marker panel for Nigeria- Cameroonian chimpanzees.Journal of genetics · 2020Article
- Population relationships based on 170 ancestry SNPs from the combined Kidd and Seldin panels.Scientific reports · 2019Article
- Identifying novel microhaplotypes for ancestry inference.International journal of legal medicine · 2019Article
- Exploring the ancestry differentiation and inference capacity of the 28-plex AISNPs.International journal of legal medicine · 2019Article
- Using Ancestry Informative Markers (AIMs) to Detect Fine Structures Within Gorilla Populations.Frontiers in genetics · 2019Article
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6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUsing DNA to determine an individual's ancestry from among human populations is generally interesting and useful for many purposes, including admixture mapping, controlling for population structure in disease or trait association studies and forensic ancestry inference. However, to estimate ancestry, including possible admixture within an individual, as well as heterogeneity within a group of individuals, allele frequencies are necessary for what are believed to be the contributing populations. For this purpose, panels of ancestry informative markers (AIMs) have been developed.
resultsWe are presenting our work on one such panel, composed of 128 ancestry informative single-nucleotide polymorphisms (AISNPs) already proposed in the literature. Compared to previous studies of these AISNPs, we have studied three times the number of individuals (4,871) in three times as many population samples (119). We have validated this panel for many ancestry assignment and admixture studies, especially those that were the rationale for the original selection of the 128 SNPs: African Americans and Mexican Americans. At the same time, the limitations of the panel for distinguishing ancestry and quantifying admixture among Eurasian populations are noted.
conclusionWe demonstrate the simultaneous importance of the specific set of population samples and their relative sample sizes in the use of the structure program to determine which groups cluster together and consequently influence the ability of a marker panel to infer ancestry. We demonstrate the strengths and weaknesses of this particular panel of AISNPs in a global context.
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