ArticleFEMS immunology and medical microbiology2011
ALS51, a newly discovered gene in the Candida albicans ALS family, created by intergenic recombination: analysis of the gene and protein, and implications for evolution of microbial gene families.
Article in FEMS immunology and medical microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 24 citations in OpenAlex.
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- Development and validation of monoclonal antibodies specific for Candida albicans Als2, Als9-1, and Als9-2.PloS one · 2022Article
- Pursuing Advances in DNA Sequencing Technology to Solve a Complex Genomic Jigsaw Puzzle: The Agglutinin-Like Sequence (Frontiers in microbiology · 2020Article
- Tandem repeats lead to sequence assembly errors and impose multi-level challenges for genome and protein databases.Nucleic acids research · 2019Review
- Partner Choice in Spontaneous Mitotic Recombination in Wild Type and Homologous Recombination Mutants ofG3 (Bethesda, Md.) · 2019Article
- Review
- Agglutinin-Like Sequence (Frontiers in microbiology · 2019Article
- Candida albicans Agglutinin-Like Sequence (Als) Family Vignettes: A Review of Als Protein Structure and Function.Frontiers in microbiology · 2016Review
- The peptide-binding cavity is essential for Als3-mediated adhesion of Candida albicans to human cells.The Journal of biological chemistry · 2014Article
- A proposed mechanism for the interaction between the Candida albicans Als3 adhesin and streptococcal cell wall proteins.Frontiers in microbiology · 2014Article
- A monoclonal antibody specific for Candida albicans Als4 demonstrates overlapping localization of Als family proteins on the fungal cell surface and highlights differences between Als localization in vitro and in vivo.FEMS immunology and medical microbiology · 2012Article
- Evaluation of the role of Candida albicans agglutinin-like sequence (Als) proteins in human oral epithelial cell interactions.PloS one · 2012Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The Candida albicans ALS family has eight genetic loci, each encoding a large glycoprotein. Als protein function is discussed most frequently in terms of adhesion to host and abiotic surfaces. Analyses of C. albicans strain WO-1 indicated variation within the ALS1 locus compared with other isolates such as SC5314. Investigation revealed a recombination between the contiguous ALS5 and ALS1 loci to generate a new coding region, named ALS51, because it encodes the 5' domain of ALS5 fused in-frame to the tandem repeat region and 3' domain of ALS1. ALS51 was detected in 11 isolates (4.6%) from a collection of 239 C. albicans strains of diverse origin and clade assignment. The 12 ALS51-positive strains identified in this study represented three different ALS family genotypes with respect to the presence and copy number of ALS51, ALS5 and ALS1. ALS51 transcription was detected by real-time reverse-transcription-PCR in WO-1. Although the cell-surface abundance of Als51 on WO-1 and Als5 on SC5314 was too low to visualize by indirect immunofluorescence using an anti-Als5 monoclonal antibody, both proteins were observed on Western blots of β-1,6-glucanase-digested C. albicans cell walls. Characterization of ALS51 illustrates one of the recombination mechanisms that generate diversity within C. albicans gene families.
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