ArticleBehavior genetics2011
Genetic variation in the KIAA0319 5' region as a possible contributor to dyslexia.
Article in Behavior genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Opposite Associations between Individual KIAA0319 Polymorphisms and Developmental Dyslexia Risk across Populations: A Stratified Meta-Analysis by the Study Population.Scientific reports · 2016Pooled it
- A family-based association analysis and meta-analysis of the reading disabilities candidate gene DYX1C1.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2013Pooled it
- Language and reading impairments are associated with increased prevalence of non-right-handedness.Child developmentPooled it
- Neural Cell Models of Specific Reading Disabilities: Identification of Cellular and Transcriptome Alterations.Genes, brain, and behavior · 2026Article
- Targeted analysis of dyslexia-associated regions on chromosomes 6, 12 and 15 in large multigenerational cohorts.PloS one · 2025Article
- Specific Learning Disorders: Variation Analysis of 15 Candidate Genes in 9 Multiplex Families.Medicina (Kaunas, Lithuania) · 2023Article
- Identification of brain cell types underlying genetic association with word reading and correlated traits.Molecular psychiatry · 2023Article
- Identification of Phonology-Related Genes and Functional Characterization of Broca's and Wernicke's Regions in Language and Learning Disorders.Frontiers in neuroscience · 2021Article
- Neural Noise Hypothesis of Developmental Dyslexia.Trends in cognitive sciences · 2017Review
- The Roles of Genes in the Neuronal Migration and Neurite Outgrowth Network in Developmental Dyslexia: Single- and Multiple-Risk Genetic Variants.Molecular neurobiology · 2016Article
- KIAA0319 gene polymorphisms are associated with developmental dyslexia in Chinese Uyghur children.Journal of human genetics · 2016Article
- The regulatory element READ1 epistatically influences reading and language, with both deleterious and protective alleles.Journal of medical genetics · 2016Article
- Decoding the non-coding genome: elucidating genetic risk outside the coding genome.Genes, brain, and behavior · 2016Review
- Characterization of the DYX2 locus on chromosome 6p22 with reading disability, language impairment, and IQ.Human genetics · 2014Article
- Association of the ROBO1 gene with reading disabilities in a family-based analysis.Genes, brain, and behavior · 2014Article
- KIAA0319 and ROBO1: evidence on association with reading and pleiotropic effects on language and mathematics abilities in developmental dyslexia.Journal of human genetics · 2014Article
- Imaging-genetics in dyslexia: connecting risk genetic variants to brain neuroimaging and ultimately to reading impairments.Molecular genetics and metabolism · 2013Review
- The effects of Kiaa0319 knockdown on cortical and subcortical anatomy in male rats.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2013Article
- Neocortical disruption and behavioral impairments in rats following in utero RNAi of candidate dyslexia risk gene Kiaa0319.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2012Article
- The genetics of reading disabilities: from phenotypes to candidate genes.Frontiers in psychology · 2012Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Reading disabilities (RD) have been linked and associated with markers on chromosome 6p with results from multiple independent samples pointing to KIAA0319 as a risk gene and specifically, the 5' region of this gene. Here we focus genetic studies on a 2.3 kb region spanning the predicted promoter, the first untranslated exon, and part of the first intron, a region we identified as a region of open chromatin. Using DNA from probands with RD, we screened for genetic variants and tested select variants for association. We identified 17 DNA variants in this sample of probands, 16 of which were previously reported in public databases and one previously identified in a screen of this region. Based on the allele frequencies in the probands compared to public databases, and on possible functional consequences of the variation, we selected seven variants to test for association in a sample of families with RD, in addition to four variants which had been tested previously. We also tested two markers 5' of this region that were previously reported as associated. The strongest evidence for association was observed with alleles of the microsatellite marker located in the first untranslated exon and haplotypes of that marker. These results support previous studies indicating the 5' region of the KIAA0319 gene as the location of risk alleles contributing to RD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.