ArticleBehavior genetics2011
A family based association study of DRD4, DAT1, and 5HTT and continuous traits of attention-deficit hyperactivity disorder.
Article in Behavior genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Association study and a systematic meta-analysis of the VNTR polymorphism in the 3'-UTR of dopamine transporter gene and attention-deficit hyperactivity disorder.Journal of neural transmission (Vienna, Austria : 1996) · 2019Pooled it
- Selective Visual Attention in ADHD: A Narrative Review.Current neurology and neuroscience reports · 2025Review
- Glutamate receptor genetic variants affected peripheral glutamatergic transmission and treatment induced improvement of Indian ADHD probands.Scientific reports · 2023Article
- A novel hypervariable variable number tandem repeat in the dopamine transporter gene (Life science alliance · 2023Article
- ADHD symptoms and school impairment history in parents of ADHD children are a fundamental diagnostic and therapeutic clue.Italian journal of pediatrics · 2022Article
- Attention-deficit/hyperactive disorder updates.Frontiers in molecular neuroscience · 2022Review
- Disruptive Behavior in Siblings Discordant for Exposure to Maternal Smoking During Pregnancy: A Multi-rater Approach.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2020Article
- Short-active photoperiod gestation induces psychiatry-relevant behavior in healthy mice but a resiliency to such effects are seen in mice with reduced dopamine transporter expression.Scientific reports · 2020Article
- Guanfacine treatment improves ADHD phenotypes of impulsivity and hyperactivity in a neurofibromatosis type 1 mouse model.Journal of neurodevelopmental disorders · 2020Article
- A Review of Heterogeneity in Attention Deficit/Hyperactivity Disorder (ADHD).Frontiers in human neuroscience · 2019Review
- Genetic associations between ADHD and dopaminergic genes (DAT1 and DRD4) VNTRs in Korean children.Genes & genomics · 2018Article
- Neurochemical changes in basal ganglia affect time perception in parkinsonians.Journal of biomedical science · 2018Review
- DRD4 Gene Polymorphisms as a Risk Factor for Children with Attention Deficit Hyperactivity Disorder in Iranian Population.International scholarly research notices · 2017Article
- Smoking during pregnancy and ADHD risk: A genetically informed, multiple-rater approach.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2016Article
- Moving towards causality in attention-deficit hyperactivity disorder: overview of neural and genetic mechanisms.The lancet. Psychiatry · 2016Review
- Attention deficit hyperactivity disorder: genetic association study in a cohort of Spanish children.Behavioral and brain functions : BBF · 2016Article
- MAOA Influences the Trajectory of Attentional Development.Frontiers in human neuroscience · 2016Article
- Symptoms of attention-deficit hyperactivity disorder, nonsyndromic orofacial cleft children, and dopamine polymorphisms: a pilot study.Biological research for nursing · 2015Article
- DRD4 long allele carriers show heightened attention to high-priority items relative to low-priority items.Journal of cognitive neuroscience · 2015Article
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Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Despite its high heritability, genetic association studies of attention deficit-hyperactivity disorder (ADHD) have often resulted in somewhat small, inconsistent effects. Refining the ADHD phenotype beyond a dichotomous diagnosis and testing associations with continuous information from the underlying symptom dimensions may result in more consistent genetic findings. This study further examined the association between ADHD and the DRD4, DAT1, and 5HTT genes by testing their association with multivariate phenotypes derived from continuous measures of ADHD symptom severity. DNA was collected in 202 families consisting of at least one ADHD proband and at least one parent or sibling. VNTR polymorphisms of the DRD4 and DAT1 genes were significantly associated with the continuous ADHD phenotype. The association with DRD4 was driven by both inattentive and hyperactive symptoms, while the association with DAT1 was driven primarily by inattentive symptoms. These results use novel methods to build upon important connections between dopamine genes and their final behavioral manifestation as symptoms of ADHD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.