ReviewClinical reviews in allergy & immunology2012
The diagnostic and clinical significance of anti-muscarinic receptor autoantibodies.
Review in Clinical reviews in allergy & immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Sex-specific and polygenic effects underlying resting heart rate and associated risk of cardiovascular disease.European journal of preventive cardiology · 2024Pooled it
- Preprocedural M2-muscarinic acetylcholine receptor autoantibody levels predict left atrial low-voltage area severity in atrial fibrillation undergoing catheter ablation.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026Article
- Initial characterization of MNaunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Transcutaneous vagus nerve stimulation attenuates autoantibody-mediated cardiovagal dysfunction and inflammation in a rabbit model of postural tachycardia syndrome.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2023Article
- Impact of autoantibodies against the M2-muscarinic acetylcholine receptor on clinical outcomes in peripartum cardiomyopathy patients with standard treatment.BMC cardiovascular disorders · 2021Observational
- The Role of Autoantibodies in Arrhythmogenesis.Current cardiology reports · 2020Review
- Pro-Arrhythmic Signaling of Thyroid Hormones and Its Relevance in Subclinical Hyperthyroidism.International journal of molecular sciences · 2020Review
- A historic perspective on the current progress in elucidation of the biologic significance of non-neuronal acetylcholine.International immunopharmacology · 2020Article
- Article
- Autoimmunity in Chronic Chagas Disease: A Road of Multiple Pathways to Cardiomyopathy?Frontiers in immunology · 2018Review
- Regulatory Role of CD4Journal of immunology research · 2018Review
- The Contribution of Autoantibodies to Inflammatory Cardiovascular Pathology.Frontiers in immunology · 2018Review
- Autoimmunity Against the Heart and Cardiac Myosin in Children With Myocarditis.Journal of cardiac failure · 2016Article
- Less travelled roads in clinical immunology and allergy: drug reactions and the environmental influence.Clinical reviews in allergy & immunology · 2013Review
- Article
- Cutting-edge issues in autoimmunity and allergy of the digestive system.Clinical reviews in allergy & immunology · 2012Article
- Autoimmune heart disease: role of sex hormones and autoantibodies in disease pathogenesis.Expert review of clinical immunology · 2012Review
- Systemic lupus erythematosus and systemic autoimmune connective tissue disorders behind recurrent diastolic heart failure.Clinical & developmental immunology · 2012Article
- Cardiac autoantibodies from patients affected by a new variant of endemic pemphigus foliaceus in Colombia, South America.Journal of clinical immunology · 2011Article
- Crystal structure of the complex mAb 17.2 and the C-terminal region of Trypanosoma cruzi P2β protein: implications in cross-reactivity.PLoS neglected tropical diseases · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of autoimmunity in cardiovascular diseases has become one of the focal points of research studies. Autoimmune response and autoreactive autoantibodies have been found in dilated cardiomyopathy, heart failure, rheumatic fever, myocarditis, atherosclerosis, and other diseases. Autoantibodies may appear due to tissue injury and exposure of autoantigens, in addition to molecular mimicry and cross-reactivity with antigens found in infectious agents in predisposed individuals. In the early 1990s, autoantibodies reacting with the M2 muscarinic receptor were found in patients with dilated cardiomyopathy and subsequently, in patients with Chagas heart disease and arrhythmic disorders. Immunization of animals with the corresponding antigen triggered cardiac abnormalities also appearing in dilated cardiomyopathy of humans. It has been suggested that antibodies against M2 muscarinic receptors play a role in the pathogenesis of cardiac diseases and may also alter the electrophysiological properties of cardiac tissue. Herein, we review the current knowledge of antibodies against M2 muscarinic receptors and the possible use of a targeted therapy against these autoantibodies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.