Evidence map›Paper›PMID 21207099›Full record

ReviewCellular and molecular life sciences : CMLS2011

Systematic characterization of protein-DNA interactions.

Zhi Xie, Shaohui Hu, Jiang Qian, Seth Blackshaw, Heng Zhu

Abstract readReview
In one paragraph

Review in Cellular and molecular life sciences : CMLS, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. A rapid test for protein-DNA interactions.Nucleic acids research · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Regulation ofFrontiers in microbiology · 2022
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zhi XieDepartment of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Shaohui Hu
Jiang Qian
Seth Blackshaw
Heng Zhu

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sequence-specific protein-DNA interactions (PDIs) are critical for regulating many cellular processes, including transcription, DNA replication, repair, and rearrangement. We review recent experimental advances in high-throughput technologies designed to characterize PDIs and discuss recent studies that use these tools, including ChIP-chip/seq, SELEX-based approaches, yeast one-hybrid, bacterial one-hybrid, protein binding microarray, and protein microarray. The results of these studies have challenged some long-standing concepts of PDI and provide valuable insights into the complex transcriptional regulatory networks.

Indexed as

Chromatin ImmunoprecipitationDNADNA-Binding ProteinsProtein Array AnalysisSELEX Aptamer TechniqueTwo-Hybrid System TechniquesDNADNA-Binding Proteins

Identifiers

PMID21207099
PMCPMC11115113

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.