ArticleJournal of comparative physiology. B, Biochemical, systemic, and environmental physiology2011
Mitochondrial respiration and succinate dehydrogenase are suppressed early during entrance into a hibernation bout, but membrane remodeling is only transient.
Article in Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 49 citations in OpenAlex.
- Oxaloacetate inhibition of succinate dehydrogenase: mechanism and physiological implications.American journal of physiology. Cell physiology · 2026Review
- Weakened Contractile Performance and Mitochondrial Respiratory Complex Activity in Skeletal Muscle Improve during Interbout Arousal in Hibernating Daurian Ground Squirrel,International journal of molecular sciences · 2023Article
- Review
- Suppression of mitochondrial respiration by hydrogen sulfide in hibernating 13-lined ground squirrels.Free radical biology & medicine · 2021Article
- Metabolic characteristics of overwintering by the high-altitude dwelling Xizang plateau frog, Nanorana parkeri.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2020Article
- Differential posttranslational modification of mitochondrial enzymes corresponds with metabolic suppression during hibernation.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- Effect of hypothermia on the functional activity of liver mitochondria of grass snake (Natrix natrix): inhibition of succinate-fueled respiration and KJournal of bioenergetics and biomembranes · 2019Article
- Enhanced oxidative capacity of ground squirrel brain mitochondria during hibernation.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- Reversible temperature-dependent differences in brown adipose tissue respiration during torpor in a mammalian hibernator.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- Regulation of mitochondrial metabolism during hibernation by reversible suppression of electron transport system enzymes.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2017Article
- Proteomic Profiling Reveals Adaptive Responses to Surgical Myocardial Ischemia-Reperfusion in Hibernating Arctic Ground Squirrels Compared to Rats.Anesthesiology · 2016Article
- Proteomics approaches shed new light on hibernation physiology.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2015Review
- Saponin-permeabilization is not a viable alternative to isolated mitochondria for assessing oxidative metabolism in hibernation.Biology open · 2015Article
- The involvement of mRNA processing factors TIA-1, TIAR, and PABP-1 during mammalian hibernation.Cell stress & chaperones · 2014Article
- To be or not to be: the regulation of mRNA fate as a survival strategy during mammalian hibernation.Cell stress & chaperones · 2014Article
- Substrate-specific changes in mitochondrial respiration in skeletal and cardiac muscle of hibernating thirteen-lined ground squirrels.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2014Article
- The regulation of food intake in mammalian hibernators: a review.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2012Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We examined respiration and lipid composition of liver mitochondria purified from a hibernator (Ictidomys tridecemlineatus) in different stages of a torpor bout. Between interbout euthermia (body temperature, T (b), 37°C) and early entrance (T (b) 30°C), state 3 and state 4 respirations, fueled by 6 mM succinate, fell by over 50%. Mitochondrial respiration did not decline any further in the late entrance and torpor stages (T (b) 15 and 5°C, respectively). Succinate dehydrogenase (SDH) activity declined in a similar pattern as mitochondrial respiration, and there was a significant positive correlation between state 3 respiration and SDH activity. However, unlike during arousal from torpor, oxaloacetate was not a major factor in inhibition of SDH. Analysis of mitochondrial lipids showed little change in neutral lipids or phospholipid classes, except for a transient decrease in phosphatidylethanolamine content in early entrance. In the transition from interbout euthermia to early entrance, we found transient increases in some saturated phospholipid fatty acids (16:0, 18:0) and decreases in some unsaturates (18:2, 20:4). These changes resulted in transient increases in total saturates and the ratio of saturates to unsaturates, and transient decreases in total unsaturates, total polyunsaturates, total n-6, the ratio of monounsaturates to polyunsaturates, and unsaturation index. None of these changes persisted into late entrance or torpor, nor did they correlate with mitochondrial respiration. We conclude that mitochondrial metabolic suppression during entrance into a torpor bout occurs very early and is likely related to acute regulation of electron transport chain enzymes rather than changes in membrane phospholipid composition.
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