ArticleDer Urologe. Ausg. A2011
[The influence of diabetes mellitus on male reproductive function: a poorly investigated aspect of male infertility].
Article in Der Urologe. Ausg. A, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 49 citations in OpenAlex.
- The link between diabetes and male infertility: mechanisms and implications.Scientific reports · 2026Article
- Policosanol ameliorates testicular injury and improves steroidogenesis in diabetic hypercholesterolemic rats.Molecular biology reports · 2025Article
- Diabetes and male infertility: A review of sperm chromatin damage and epigenetic effects.International journal of reproductive biomedicine · 2025Review
- Effect of saponin on spermatogenesis and testicular structure in streptozotocin-induced diabetic mice.Veterinary research forum : an international quarterly journal · 2023Article
- Phytomedicinal therapeutics for male infertility: critical insights and scientific updates.Journal of natural medicines · 2022Review
- Resveratrol attenuates reproductive alterations in type 1 diabetes-induced rats.International journal of experimental pathology · 2017Article
- Investigating the effects of Citrullus colocynthis pulp on oxidative stress in testes and epididymis in streptozotocin-induced diabetic male rats.International journal of reproductive biomedicine · 2017Article
- Ameliorative Effect of Zinc Oxide Nanoparticles on Antioxidants and Sperm Characteristics in Streptozotocin-Induced Diabetic Rat Testes.BioMed research international · 2015Article
- Modulation of diabetes-mellitus-induced male reproductive dysfunctions in experimental animal models with medicinal plants.Pharmacognosy reviews · 2014Review
- The anti-oxidant effects of ginger and cinnamon on spermatogenesis dys-function of diabetes rats.African journal of traditional, complementary, and alternative medicines : AJTCAM · 2014Article
- Dracaena arborea alleviates ultra-structural spermatogenic alterations in streptozotocin-induced diabetic rats.BMC complementary and alternative medicine · 2013Article
- Decreased spermatogenesis, fertility, and altered Slc2A expression in Akt1-/- and Akt2-/- testes and sperm.Reproductive sciences (Thousand Oaks, Calif.) · 2012Article
- Seminal Oxidative Stress Markers, Calcium, Magnesium, and Semen Profile of Infertile Diabetic and Nondiabetic Nigerian Men.International journal of applied & basic medical researchArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Whilst diabetes mellitus is known to have many systemic complications, male infertility, beyond impotence, retrograde ejaculation and hypogonadism, has not been widely recognised to be one of them. Due to the paucity of studies and inconsistencies regarding the condition's impact on semen quality, few fertility specialists consider the condition noteworthy. As a consequence little information exists as to its prevalence amongst infertile men. Recently the prevailing view has been challenged by findings showing that diabetes induces subtle molecular changes that are important for sperm quality and function. Diabetic men have been found to have a significantly higher percentage of sperm with nuclear DNA damage, a factor known to be associated with compromised fertility and increased miscarriage rates. The mechanism by which this diabetes-related sperm nDNA damage occurs remains unknown. The identification of high levels of advanced glycation end products (AGEs) and their receptor (RAGE) throughout the male reproductive tract coupled to changes in testicular metabolite levels and spermatogenic gene expression suggest that glycation may play an integral role in oxidative stress which in turn causes sperm nDNA damage. As glycation is a normal consequence of life and has been implicated in DNA fragmentation in a variety of seemingly unconnected conditions, it may constitute a common mechanism for the damage seen in sperm DNA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.