ArticleFrontiers in behavioral neuroscience2010
A Neurogenetic Dissociation between Punishment-, Reward-, and Relief-Learning in Drosophila.
Article in Frontiers in behavioral neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Octopamine receptors inFrontiers in molecular neuroscience · 2026Article
- An octopamine-specific GRAB sensor reveals a monoamine relay circuitry that boosts aversive learning.National science review · 2024Article
- An octopamine-specific GRAB sensor reveals a monoamine relay circuitry that boosts aversive learning.bioRxiv : the preprint server for biology · 2024Article
- Dopamine activity in projection neurons regulates short-lasting olfactory approach memory in Drosophila.The European journal of neuroscience · 2022Article
- Memory enhancement by ferulic acid ester across species.Science advances · 2018Article
- Reinforcement signaling of punishment versus relief in fruit flies.Learning & memory (Cold Spring Harbor, N.Y.) · 2018Article
- Drosophila mutants lacking octopamine exhibit impairment in aversive olfactory associative learning (Commentary on Iliadi et al. (2017)).The European journal of neuroscience · 2017Article
- Neural Circuits Underlying Fly Larval Locomotion.Current pharmaceutical design · 2017Review
- Independent natural genetic variation of punishment- versus relief-memory.Biology letters · 2016Article
- Metabotropic Glutamate Receptors 7 within the Nucleus Accumbens are Involved in Relief Learning in Rats.Current neuropharmacology · 2016Article
- Synapsin determines memory strength after punishment- and relief-learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Reversing Stimulus Timing in Visual Conditioning Leads to Memories with Opposite Valence in Drosophila.PloS one · 2015Article
- Pain-relief learning in flies, rats, and man: basic research and applied perspectives.Learning & memory (Cold Spring Harbor, N.Y.) · 2014Review
- Using microfluidics chips for live imaging and study of injury responses in Drosophila larvae.Journal of visualized experiments : JoVE · 2014Article
- Optogenetic induction of aversive taste memory.Neuroscience · 2012Article
- Article
- Event timing in associative learning: from biochemical reaction dynamics to behavioural observations.PloS one · 2012Article
Corrections and comments
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Authors and funding
2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
What is particularly worth remembering about a traumatic experience is what brought it about, and what made it cease. For example, fruit flies avoid an odor which during training had preceded electric shock punishment; on the other hand, if the odor had followed shock during training, it is later on approached as a signal for the relieving end of shock. We provide a neurogenetic analysis of such relief learning. Blocking, using UAS-shibire(ts1), the output from a particular set of dopaminergic neurons defined by the TH-Gal4 driver partially impaired punishment learning, but left relief learning intact. Thus, with respect to these particular neurons, relief learning differs from punishment learning. Targeting another set of dopaminergic/serotonergic neurons defined by the DDC-Gal4 driver on the other hand affected neither punishment nor relief learning. As for the octopaminergic system, the tbh(M18) mutation, compromising octopamine biosynthesis, partially impaired sugar-reward learning, but not relief learning. Thus, with respect to this particular mutation, relief learning, and reward learning are dissociated. Finally, blocking output from the set of octopaminergic/tyraminergic neurons defined by the TDC2-Gal4 driver affected neither reward, nor relief learning. We conclude that regarding the used genetic tools, relief learning is neurogenetically dissociated from both punishment and reward learning. This may be a message relevant also for analyses of relief learning in other experimental systems including man.
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