ArticleTherapeutics and clinical risk management2010
Reduced exercise capacity in persons with Down syndrome: cause, effect, and management.
Article in Therapeutics and clinical risk management, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03058640 (The Effects of Participation in Karate on Health Outcomes in Adolescents With Down Syndrome), which is not on this map. Cited by 38 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effects of Participation in Karate on Health Outcomes in Adolescents With Down Syndrome
Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 103 citations in OpenAlex.
- Meta-analysis of metabolites involved in bioenergetic pathways reveals a pseudohypoxic state in Down syndrome.Molecular medicine (Cambridge, Mass.) · 2020Pooled it
- Outcomes of an Exercise Intervention in Adults With Down Syndrome and Congenital Heart Disease: A Secondary Analysis.Journal of intellectual disability research : JIDR · 2026Trial
- Effects of Resistance Training in Muscle Mass and Markers of Muscle Damage in Adults with Down Syndrome.International journal of environmental research and public health · 2021Trial
- A Short-Term Resistance Training Circuit Improved Antioxidants in Sedentary Adults with Down Syndrome.Oxidative medicine and cellular longevity · 2021Trial
- Accelerometer-based 24-h movement behaviours in children and adolescents with Down syndrome.European journal of pediatrics · 2026Article
- Play to move: A mixed-methods prospective observational study of exergaming versus traditional exercise interventions in children with Down syndrome.The Journal of international medical research · 2026Observational
- Single-beat method echocardiographic comparison of ventricular-arterial coupling in adults with and without Down syndrome.American journal of physiology. Heart and circulatory physiology · 2026Article
- Test-retest reliability of the Test of Gross Motor Development-3 instrument for children with Down syndrome.African journal of disability · 2026Article
- Association Between Physical Fitness and Quality of Life in Children and Adolescents with Down Syndrome.Children (Basel, Switzerland) · 2025Article
- Body Composition and Adiposity in Children with Down Syndrome Compared to Typically Developing Children: The Association with Their Motor Performance.Children (Basel, Switzerland) · 2025Article
- Cerebral oxygenation during submaximal and peak exercise for sedentary adults with and without down syndrome.Frontiers in physiology · 2025Article
- Strength versus aerobic program: effects on body composition and health-related physical fitness levels of youths with Down syndrome.International journal of developmental disabilities · 2024Article
- Physical Activity Patterns in Adolescents and Adults with Intellectual and Developmental Disabilities.Exercise, sport & movement · 2024Article
- Effects of exercise programs on cardiovascular responses in individuals with down syndrome: A systematic review and meta-analysis.Preventive medicine reports · 2023Review
- Development of a Physical Therapy-Based Exercise Program for Adults with Down Syndrome.International journal of environmental research and public health · 2023Review
- Gender Differences, Motor Skills and Physical Fitness Heterogeneity in Adults with Down's Syndrome.Journal of clinical medicine · 2023Article
- Parental perception of facilitators and barriers to health among young children with down syndrome: a qualitative study.Frontiers in pediatrics · 2023Article
- Sleep apnea in people with Down syndrome: Causes and effects of physical activity?Frontiers in neurology · 2023Review
- Comprehensive cardiopulmonary profile of individuals with Down syndrome.Journal of intellectual disability research : JIDR · 2022Article
- The Impact of Oxidative Stress on Pediatrics Syndromes.Antioxidants (Basel, Switzerland) · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Persons with Down syndrome (DS) have reduced peak and submaximal exercise capacity. Because ambulation is one predictor of survival among adults with DS, a review of the current knowledge of the causes, effects, and management of reduced exercise capacity in these individuals would be important. Available data suggest that reduced exercise capacity in persons with DS results from an interaction between low peak oxygen uptake (VO(2peak)) and poor exercise economy. Of several possible explanations, chronotropic incompetence has been shown to be the primary cause of low VO(2peak) in DS. In contrast, poor exercise economy is apparently dependent on disturbed gait kinetics and kinematics resulting from joint laxity and muscle hypotonia. Importantly, there is enough evidence to suggest that such low levels of physical fitness (reduced exercise capacity and muscle strength) limit the ability of adults with DS to perform functional tasks of daily living. Consequently, clinical management of reduced exercise capacity in DS seems important to ensure that these individuals remain productive and healthy throughout their lives. However, few prospective studies have examined the effects of structured exercise training in this population. Existent data suggest that exercise training is beneficial for improving exercise capacity and physiological function in persons with DS. This article reviews the current knowledge of the causes, effects, and management of reduced exercise capacity in DS. This review is limited to the acute and chronic responses to submaximal and peak exercise intensities because data on supramaximal exercise capacity of persons with DS have been shown to be unreliable.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.