Evidence map›Paper›PMID 21206541›Full record

ArticleSurgical neurology international2010

Natural anti-inflammatory agents for pain relief.

Joseph C Maroon, Jeffrey W Bost, Adara Maroon

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Surgical neurology international, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05896878 (The Effects of Daily Anti-inflammatory Supplementation on Foundation Pain Index Scores in Chronic Opiate Patients), which is not on this map. Cited by 102 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
102citing papers in PubMed, 6 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05896878 naterminatednot on this mapstarted 2023, after this paper: background citation

The Effects of Daily Anti-inflammatory Supplementation on Foundation Pain Index Scores in Chronic Opiate Patients

TypeinterventionalSponsorHudson MedicalRan2023 to 2024Enrolled1ConditionsPain, Chronic, Opioid Dependence, Opioid Use, Inflammation ChronicArmsRoot.Health Dietary Supplement
3 · Its place in the literature

Who cites it

102 citing papers in PubMed, 6 syntheses or guidelines pooled it, 290 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Relief of pain due to uterine cramping/involution after birth.The Cochrane database of systematic reviews · 2020
    Pooled it
  5. Pooled it
  6. Pooled it
  7. Trial
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  13. Article
  14. Review
  15. Neuroprotective Pathway Modulation by a NovelInternational journal of molecular sciences · 2025
    Article
  16. Review
  17. Article
  18. Article
  19. Phytochemical Analysis and Phytometabolomic Profiling ofInternational journal of molecular sciences · 2025
    Article
  20. Article

42 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Joseph C MaroonDepartment of Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Jeffrey W Bost
Adara Maroon
University of Pittsburgh Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The use of both over-the-counter and prescription nonsteroidal medications is frequently recommended in a typical neurosurgical practice. But persistent long-term use safety concerns must be considered when prescribing these medications for chronic and degenerative pain conditions. This article is a literature review of the biochemical pathways of inflammatory pain, the potentially serious side effects of nonsteroidal drugs and commonly used and clinically studied natural alternative anti-inflammatory supplements. Although nonsteroidal medications can be effective, herbs and dietary supplements may offer a safer, and often an effective, alternative treatment for pain relief, especially for long-term use.

Indexed as

Alternative treatmentsinflammationnatural anti-inflammatoriespain

Identifiers

PMID21206541
PMCPMC3011108
OpenAlexW2105202353

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.