ReviewRNA (New York, N.Y.)2011
Proofreading and spellchecking: a two-tier strategy for pre-mRNA splicing quality control.
Review in RNA (New York, N.Y.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- Pervasive noise in human pre-mRNA splice site selection.Molecular cell · 2026Article
- The G-patch protein Cwf28 interacts with the RNA helicase Cdc28 in catalytically active spliceosomes in Schizosaccharomyces pombe.PloS one · 2026Article
- Structures of aberrant spliceosome intermediates on their way to disassembly.Nature structural & molecular biology · 2025Article
- Nuclear mRNA Quality Control and Cytoplasmic NMD Are Linked by the Guard Proteins Gbp2 and Hrb1.International journal of molecular sciences · 2021Review
- UBL5/Hub1: An Atypical Ubiquitin-Like Protein with a Typical Role as a Stress-Responsive Regulator.International journal of molecular sciences · 2021Review
- Multiplex RNA-based detection of clinically relevant MET alterations in advanced non-small cell lung cancer.Molecular oncology · 2021Article
- Splicing heterogeneity: separating signal from noise.Genome biology · 2018Article
- Integration of mRNP formation and export.Cellular and molecular life sciences : CMLS · 2017Review
- Prp4 Kinase Grants the License to Splice: Control of Weak Splice Sites during Spliceosome Activation.PLoS genetics · 2016Article
- Single Molecule Cluster Analysis dissects splicing pathway conformational dynamics.Nature methods · 2015Article
- Introns and gene expression: cellular constraints, transcriptional regulation, and evolutionary consequences.BioEssays : news and reviews in molecular, cellular and developmental biology · 2015Article
- Biological and clinical significance of epigenetic silencing of MARVELD1 gene in lung cancer.Scientific reports · 2014Article
- smFRET studies of the 'encounter' complexes and subsequent intermediate states that regulate the selectivity of ligand binding.FEBS letters · 2014Review
- Spliceosome-mediated decay (SMD) regulates expression of nonintronic genes in budding yeast.Genes & development · 2013Article
- Transcriptome analysis of human tissues and cell lines reveals one dominant transcript per gene.Genome biology · 2013Article
- Splicing proofreading at 5' splice sites by ATPase Prp28p.Nucleic acids research · 2013Article
- Article
- RNA helicases in splicing.RNA biology · 2013Review
- The development and application of small molecule modulators of SF3b as therapeutic agents for cancer.Drug discovery today · 2013Review
- The spliceosome as a target of novel antitumour drugs.Nature reviews. Drug discovery · 2012Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Multi-tier strategies exist in many biochemical processes to ensure a maximal fidelity of the reactions. In this review, we focus on the two-tier quality control strategy that ensures the quality of the products of the pre-mRNA splicing reactions catalyzed by the spliceosome. The first step in the quality control process relies on kinetic proofreading mechanisms that are internal to the spliceosome and that are performed by ATP-dependent RNA helicases. The second quality control step, spellchecking, involves recognition of unspliced pre-mRNAs or aberrantly spliced mRNAs that have escaped the first proofreading mechanisms, and subsequent degradation of these molecules by degradative enzymes in the nucleus or in the cytoplasm. This two-tier quality control strategy highlights a need for high fidelity and a requirement for degradative activities that eliminate defective molecules. The presence of multiple quality control activities during splicing underscores the importance of this process in the expression of genetic information.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.