ArticleThe Journal of biological chemistry2011
E2 ligase dRad6 regulates DMP53 turnover in Drosophila.
Article in The Journal of biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Synthetic biology approaches to generate temperature-sensitive alleles for the Sterile Insect Technique.Insect science · 2026Review
- Towards reconstructing the dipteran demise of an ancient essential gene: E3 ubiquitin ligase Murine double minute.Development genes and evolution · 2020Article
- Epigenetic regulation of the Warburg effect by H2B monoubiquitination.Cell death and differentiation · 2020Article
- High expression of ubiquitin-conjugating enzyme E2A predicts poor prognosis in hepatocellular carcinoma.Oncology letters · 2018Article
- A conserved RAD6-MDM2 ubiquitin ligase machinery targets histone chaperone ASF1A in tumorigenesis.Oncotarget · 2015Article
- Corp Regulates P53 in Drosophila melanogaster via a Negative Feedback Loop.PLoS genetics · 2015Article
- RAD6 promotes homologous recombination repair by activating the autophagy-mediated degradation of heterochromatin protein HP1.Molecular and cellular biology · 2015Article
- Low levels of p53 protein and chromatin silencing of p53 target genes repress apoptosis in Drosophila endocycling cells.PLoS genetics · 2014Article
- Human RAD6 promotes G1-S transition and cell proliferation through upregulation of cyclin D1 expression.PloS one · 2014Article
- Transcription-associated histone modifications and cryptic transcription.Biochimica et biophysica acta · 2013Review
- Histone H2B lysine 120 monoubiquitination is required for embryonic stem cell differentiation.Cell research · 2012Article
- RAD6 regulates the dosage of p53 by a combination of transcriptional and posttranscriptional mechanisms.Molecular and cellular biology · 2012Article
- Baculovirus infection induces a DNA damage response that is required for efficient viral replication.Journal of virology · 2011Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The turnover of tumor suppressor p53 is critical for its role in various cellular events. However, the pathway that regulates the turnover of the Drosophila melanogaster DMP53 is largely unknown. Here, we provide evidence for the first time that the E2 ligase, Drosophila homolog of Rad6 (dRad6/Dhr6), plays an important role in the regulation of DMP53 turnover. Depletion of dRad6 results in DMP53 accumulation, whereas overexpression of dRad6 causes enhanced DMP53 degradation. We show that dRad6 specifically interacts with DMP53 at the transcriptional activation domain and regulates DMP53 ubiquitination. Loss of dRad6 function in transgenic flies leads to lethalities and altered morphogenesis. The dRad6-induced defects in cell proliferation and apoptosis are found to be DMP53-dependent. The loss of dRad6 induces an accumulation of DMP53 that enhances the activation of apoptotic genes and leads to apoptosis in the presence of stress stimuli. In contrast to that, the E3 ligase is the primary factor that regulates p53 turnover in mammals, and this work demonstrates that the E2 ligase dRad6 is critical for the control of DMP53 degradation in Drosophila.
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