ArticleCancer prevention research (Philadelphia, Pa.)2011
Time to think outside the (genetic) box.
Article in Cancer prevention research (Philadelphia, Pa.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Breast Cancer beyond the Age of Mutation.Gerontology · 2016Article
- The fate is not always written in the genes: epigenomics in epidemiologic studies.Environmental and molecular mutagenesis · 2013Review
- There is a world beyond protein mutations: the role of non-coding RNAs in melanomagenesis.Experimental dermatology · 2013Article
- Genome-wide profiles of CtBP link metabolism with genome stability and epithelial reprogramming in breast cancer.Nature communications · 2013Article
- Peripheral blood DNA methylation profiles are indicative of head and neck squamous cell carcinoma: an epigenome-wide association study.Epigenetics · 2012Article
- Promoter methylation of candidate genes associated with familial testicular cancer.International journal of molecular epidemiology and genetics · 2012Article
- Perspective: The big C - for Chemoprevention.Nature · 2011Article
Corrections and comments
- Comment on
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many patients develop cancers that have clinical features of inherited syndromes (e.g., young age of onset and unique pathology) but lack mutations in the genes characteristic of the disease. In this issue of the journal, Wong et al. report that somatic epigenetic inactivation could explain some such cases in the setting of BRCA1-associated breast cancer. Here, we discuss the implications of this work in terms of the etiology, risk, and potential prevention of cancer.
Indexed as
Identifiers
21205738What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.