ArticleNeurology2011
Thalamofrontal neurodevelopment in new-onset pediatric idiopathic generalized epilepsy.
Article in Neurology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Article
- Article
- Altered Structural Network in Newly Onset Childhood Absence Epilepsy.Journal of clinical neurology (Seoul, Korea) · 2020Article
- Evaluation of cortical thickness and brain volume on 3 Tesla magnetic resonance imaging in children with frontal lobe epilepsy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Article
- Cognitive Function in Genetic Generalized Epilepsies: Insights From Neuropsychology and Neuroimaging.Frontiers in neurology · 2020Review
- Thalamic volume reduction in drug-naive patients with new-onset genetic generalized epilepsy.Epilepsia · 2018Article
- Subcortical grey matter changes in juvenile myoclonic epilepsy.NeuroImage. Clinical · 2018Article
- White Matter Abnormalities in Patients with Treatment-Resistant Genetic Generalized Epilepsies.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
- Cognitive impairment in childhood onset epilepsy: up-to-date information about its causes.Korean journal of pediatrics · 2016Review
- Impaired development of intrinsic connectivity networks in children with medically intractable localization-related epilepsy.Human brain mapping · 2014Article
- Diffusional kurtosis imaging reveals a distinctive pattern of microstructural alternations in idiopathic generalized epilepsy.Acta neurologica Scandinavica · 2014Article
- Neurodevelopmental alterations of large-scale structural networks in children with new-onset epilepsy.Human brain mapping · 2014Article
- Regional brain volumes and cognition in childhood epilepsy: does size really matter?Epilepsy research · 2014Article
- Neurobehavioral comorbidities of pediatric epilepsies are linked to thalamic structural abnormalities.Epilepsia · 2013Article
- Volumetric and shape analysis of thalamus in idiopathic generalized epilepsy.Journal of neurology · 2013Article
- Abnormal thalamocortical structural and functional connectivity in juvenile myoclonic epilepsy.Brain : a journal of neurology · 2012Article
- Uncovering the neurobehavioural comorbidities of epilepsy over the lifespan.Lancet (London, England) · 2012Review
- Reduced cortical thickness in children with new-onset seizures.AJNR. American journal of neuroradiology · 2012Article
- Starting at the beginning: the neuropsychological status of children with new-onset epilepsies.Epileptic disorders : international epilepsy journal with videotape · 2012Review
- Article
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Authors and funding
7 authors.
Funding
Abstract
backgroundQuantitative MRI techniques have demonstrated thalamocortical abnormalities in idiopathic generalized epilepsy (IGE). However, there are few studies examining IGE early in its course and the neurodevelopmental course of this region is not adequately defined.
objectiveWe examined the 2-year developmental course of the thalamus and frontal lobes in pediatric new-onset IGE (i.e., within 12 months of diagnosis).
methodsWe performed whole-brain MRI in 22 patients with new-onset IGE and 36 age-matched healthy controls. MRI was repeated 24 months after baseline MRI. Quantitative volumetrics were used to examine thalamic and frontal lobe volumes.
resultsThe IGE group showed significant differences in thalamic volume within 1 year of seizure onset (baseline) and went on to show thalamic volume loss at a significantly faster rate than healthy control children over the 2-year interval. The control group also showed a significantly greater increase in frontal white matter expansion than the IGE group. In contrast, frontal lobe gray matter volume differences were moderate at baseline and persisted over time, indicating similar developmental trajectories with differences early in the disease process that are maintained.
conclusionsBrain tissue abnormalities in thalamic and frontal regions can be identified very early in the course of IGE and an abnormal trajectory of growth continues over a 2-year interval.
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