ArticleJournal of the American Association for Laboratory Animal Science : JAALAS2010
Ligation of the left circumflex coronary artery with subsequent MRI and histopathology in rabbits.
Article in Journal of the American Association for Laboratory Animal Science : JAALAS, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 11 citations in OpenAlex.
- Development and Long-Term Follow-Up of an Experimental Model of Myocardial Infarction in Rabbits.Animals : an open access journal from MDPI · 2020Article
- Confocal Microscopy-Based Estimation of Parameters for Computational Modeling of Electrical Conduction in the Normal and Infarcted Heart.Frontiers in physiology · 2018Article
- Remodeling of the transverse tubular system after myocardial infarction in rabbit correlates with local fibrosis: A potential role of biomechanics.Progress in biophysics and molecular biology · 2017Article
- A novel method of standardized myocardial infarction in aged rabbits.American journal of physiology. Heart and circulatory physiology · 2017Article
- Analyzing Remodeling of Cardiac Tissue: A Comprehensive Approach Based on Confocal Microscopy and 3D Reconstructions.Annals of biomedical engineering · 2016Article
- An overview on development and application of an experimental platform for quantitative cardiac imaging research in rabbit models of myocardial infarction.Quantitative imaging in medicine and surgery · 2014Review
- Quantitative analysis of cardiac tissue including fibroblasts using three-dimensional confocal microscopy and image reconstruction: towards a basis for electrophysiological modeling.IEEE transactions on medical imaging · 2013Article
- An automated approach to analyze microstructural remodeling from confocal microscopies of ventricular myocytes from diseased hearts.Biomedizinische Technik. Biomedical engineering · 2012Article
- The allometric model in chronic myocardial infarction.Theoretical biology & medical modelling · 2012Article
- Magnetic resonance imaging (MRI) assessment of ventricular remodeling after myocardial infarction in rabbits.Comparative medicine · 2012Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Provided is the surgical procedure for ligating the left circumflex coronary artery to simulate heart ischemia by using a rabbit model. Heart rate monitored by electrocardiogram was increased at 5 min after ligation (mean ± SEM, 205 ± 13 bpm) when compared with that before ligation (170 ± 12 bpm), but returned to baseline at 25 min after ligation (183 ± 11 bpm). A marked elevation in the ST segment and reduction of the QRS wave of the electrocardiogram indicated the evolving myocardial infarct. The ejection fraction derived from MRI was decreased by 20% in the infarcted heart. The extent of necrosis and fibrosis in the myocardium due to ischemia led to decreased compliance and efficiency of the left ventricle. Masson trichrome staining showed blue-stained fibrils with the appearance of loose, threadlike scar tissue dispersed transmurally in the left ventricle and extending toward the apex. This study demonstrates the feasibility of MRI analysis of myocardial infarction in a rabbit model. The myocardial architecture, including the geometry of the myofibers which determines the contractile function of the heart, is clearly demonstrated by using cardiac MRI. Understanding the 3-dimensional arrangement of the myocardial microstructure and how remodeling of the infarcted myocardium affects cardiac function in an animal model has important implications for the study of heart disease in humans.
Indexed as
Identifiers
21205450PMC2994052W169475171What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.