ArticleJournal of the American Association for Laboratory Animal Science : JAALAS2010
Generation of a specific-pathogen-free baboon colony.
Article in Journal of the American Association for Laboratory Animal Science : JAALAS, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Nursery- vs. Mother-Reared Baboons: Reproductive Success and Health Parameters.Veterinary sciences · 2024Article
- Nonhuman primate models for SARS-CoV-2 Research: Managing demand for specific-pathogen-free (SPF) animals.Lab animal · 2021Article
- Effects of Chronic Viral Infection on Lymphocyte Populations in Middle-aged Baboons (Comparative medicine · 2021Article
- Comparative Analysis of Cellular Immune Responses in Conventional and SPF Olive Baboons (Comparative medicine · 2020Article
- Characterization of Baboon Cytomegalovirus Infection in Healthy Adult Baboons (Comparative medicine · 2019Article
- Intra-Abdominal Heterotopic Cardiac Xenotransplantation: Pearls and Pitfalls.Frontiers in cardiovascular medicine · 2019Article
- Maternal Vaccination With a Monocomponent Pertussis Toxoid Vaccine Is Sufficient to Protect Infants in a Baboon Model of Whooping Cough.The Journal of infectious diseases · 2018Article
- Article
- Local Virus Extinctions following a Host Population Bottleneck.Journal of virology · 2015Article
- Maternal and neonatal vaccination protects newborn baboons from pertussis infection.The Journal of infectious diseases · 2014Article
- Evaluation of reproduction and raising offspring in a nursery-reared SPF baboon (Papio hamadryas anubis) colony.American journal of primatology · 2013Article
- Distinct renal pathology and a chemotactic phenotype after enterohemorrhagic Escherichia coli shiga toxins in non-human primate models of hemolytic uremic syndrome.The American journal of pathology · 2013Article
- Review
- T-cell-based immunosuppressive therapy inhibits the development of natural antibodies in infant baboons.Transplantation · 2012Article
- The challenges of implementing pathogen control strategies for fishes used in biomedical research.Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · 2012Review
- Simultaneous detection of antibodies to five simian viruses in nonhuman primates using recombinant viral protein based multiplex microbead immunoassays.Journal of virological methods · 2011Article
- Are there advantages in the use of specific pathogen-free baboons in pig organ xenotransplantation models?XenotransplantationArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We undertook establishing an SPF baboon colony in response to requests from researchers. To enable the widest possible future use of SPF baboons, our aim was to develop an SPF colony of baboons (Papio hamadryas anubis) free of 12 target viruses: 5 herpesviruses, 4 retroviruses, simian virus 40, measles, and monkeypox. Infant baboons were removed from their mothers within 24 h of birth and nursery-reared. Groups of 3 to 8 age-matched conspecifics were isolated in separate rooms for 1 y while undergoing repeated testing for target viruses. During the initial 7 y of the SPF program, 171 infants were enrolled, of which 76 (44.4%) subsequently were removed from the program. Of those removed, 54 (71.0%) were culled due to breaks in virus-free status, 12 (15.8%) died of various causes, 4 (5.3%) developed seizures, and 6 (7.9%) were removed for other reasons. The most problematic viruses were baboon cytomegalovirus (25.9% of culls), Herpesvirus papio 1 (51.9%), and simian foamy virus (7.4%). Using conspecific groups of 3 to 4 infants reduced first-year program losses as compared with groups of 6 to 8. There have been 17 births in the SPF colony, and all these infants have been free of all target viruses since birth. On the basis of these results, early removal of infants from their dams, housing in small peer groups, frequent virus testing, and aggressive culling of virus-positive animals is an effective approach for development of a baboon colony free of multiple viruses.
Indexed as
Identifiers
21205446PMC2994048W2400483822What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.