Evidence map›Paper›PMID 21205434›Full record

ArticleEpidemiology and infection2011

Assessing spatiotemporal patterns of multidrug-resistant and drug-sensitive tuberculosis in a South American setting.

H Lin, S Shin, J A Blaya, Z Zhang, P Cegielski, C Contreras, L Asencios, C Bonilla, J Bayona, C J Paciorek and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epidemiology and infection, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Drug-resistance inMedChemComm · 2019
    Review
  7. Spatial clustering of drug-resistant tuberculosis in Hlabisa subdistrict, KwaZulu-Natal, 2011-2015.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2018
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Geographical heterogeneity of multidrug-resistant tuberculosis in Georgia, January 2009 to June 2011.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2014
    Article
  16. Linking surveillance with action against drug-resistant tuberculosis.American journal of respiratory and critical care medicine · 2012
    Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

H LinDivision of Global Health Equity, Brigham and Women's Hospital, Boston, USA.
S Shin
J A Blaya
Z Zhang
P Cegielski
C Contreras
L Asencios
C Bonilla
J Bayona
C J Paciorek
T Cohen

Funding

HARVARD CLINICAL AND TRANSLATIONAL SCIENCE CENTER (UL1)UL1RR025758 · NCRR · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2008 to 2011
$91.4M
Understanding and controlling antibiotic resistanceU54GM088558 · NIGMS · HARVARD SCHOOL OF PUBLIC HEALTH · PI BUCKEE, CAROLINE O'FLAHERTY · 2009 to 2018
$26.4M
Real-time surveillance to support dynamic and predictive models of MDR/XDR TBU19AI076217 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI MURRAY, MEGAN B · 2007 to 2011
$13.5M
Prevalence, risk factors and consequences of complex M. Tuberculosis infectionsDP2OD006663 · OD · BRIGHAM AND WOMEN'S HOSPITAL · PI COHEN, THEODORE H · 2010 to 2010
$2.7M
Evaluation of MDR-TB Treatment Strategies in Lima, PeruK23AI054591 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI SHIN, SONYA S · 2004 to 2006
$331k
NCRR NIH HHS UL1 RR025758NIAID NIH HHS K23 AI054591NIAID NIH HHS K23 AI054591-01NIAID NIH HHS U19 AI076217NIGMS NIH HHS U54 GM088558NIH HHS DP2 OD006663PHS HHS U19 A1076217
6 · The paper itself

Abstract

We examined the spatiotemporal distribution of laboratory-confirmed multidrug-resistant tuberculosis (MDR TB) cases and that of other TB cases in Lima, Peru with the aim of identifying mechanisms responsible for the rise of MDR TB in an urban setting. All incident cases of TB in two districts of Lima, Peru during 2005-2007 were included. The spatiotemporal distributions of MDR cases and other TB cases were compared with Ripley's K statistic. Of 11,711 notified cases, 1187 received drug susceptibility testing and 376 were found to be MDR. Spatial aggregation of patients with confirmed MDR disease appeared similar to that of other patients in 2005 and 2006; however, in 2007, cases with confirmed MDR disease were found to be more tightly grouped. Subgroup analysis suggests the appearance of resistance may be driven by increased transmission. Interventions should aim to reduce the infectious duration for those with drug-resistant disease and improve infection control.

Indexed as

AdultAntitubercular AgentsFemaleGeographic Information SystemsHumansMaleMycobacterium tuberculosisPeruRetrospective StudiesTuberculosisTuberculosis, Multidrug-ResistantAntitubercular Agents

Identifiers

PMID21205434
PMCPMC3153578

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.