ArticleBMC cancer2011
Loss of runt-related transcription factor 3 expression leads hepatocellular carcinoma cells to escape apoptosis.
Article in BMC cancer, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Comprehensive multi-omics analysis reveals RUNX1's prognostic value, immune associations, and MUC13-Mediated mechanistic role in hepatocellular carcinoma pathogenesis.Biochemistry and biophysics reports · 2026Article
- Cancer stem cells in hepatocellular carcinoma: therapy resistance and emerging treatments.Frontiers in immunology · 2025Review
- Review
- circLARP4 induces cellular senescence through regulating miR-761/RUNX3/p53/p21 signaling in hepatocellular carcinoma.Cancer science · 2019Article
- RUNX3 inhibits glioma survival and invasion via suppression of the β-catenin/TCF-4 signaling pathway.Journal of neuro-oncology · 2018Review
- RNAi-mediatedBioscience reports · 2017Article
- MiR-19 regulates the proliferation and invasion of glioma by RUNX3 via β-catenin/Tcf-4 signaling.Oncotarget · 2017Article
- Loss of Runt-related transcription factor 3 induces resistance to 5-fluorouracil and cisplatin in hepatocellular carcinoma.Oncology reports · 2016Article
- RUNX3 confers sensitivity to pheophorbide a-photodynamic therapy in human oral squamous cell carcinoma cell lines.Lasers in medical science · 2015Article
- Epigenetic signatures of alcohol abuse and hepatitis infection during human hepatocarcinogenesis.Oncotarget · 2014Article
- Loss of runt-related transcription factor 3 induces gemcitabine resistance in pancreatic cancer.Molecular oncology · 2013Article
- Abnormal liver differentiation and excessive angiogenesis in mice lacking Runx3.Histochemistry and cell biology · 2013Article
- Human hepatocyte carcinogenesis (review).International journal of oncology · 2013Review
- Runx3 expression in lymph nodes with metastasis is associated with the outcome of gastric cancer patients.Oncology letters · 2011Article
- Analysis of the anti-tumor effect of cetuximab using protein kinetics and mouse xenograft models.BMC research notes · 2011Article
Corrections and comments
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Authors and funding
19 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRunt-related transcription factor 3 (RUNX3) is known as a tumor suppressor gene for gastric cancer and other cancers, this gene may be involved in the development of hepatocellular carcinoma (HCC).
methodsRUNX3 expression was analyzed by immunoblot and immunohistochemistry in HCC cells and tissues, respectively. Hep3B cells, lacking endogenous RUNX3, were introduced with RUNX3 constructs. Cell proliferation was measured using the MTT assay and apoptosis was evaluated using DAPI staining. Apoptosis signaling was assessed by immunoblot analysis.
resultsRUNX3 protein expression was frequently inactivated in the HCC cell lines (91%) and tissues (90%). RUNX3 expression inhibited 90±8% of cell growth at 72 h in serum starved Hep3B cells. Forty-eight hour serum starvation-induced apoptosis and the percentage of apoptotic cells reached 31±4% and 4±1% in RUNX3-expressing Hep3B and control cells, respectively. Apoptotic activity was increased by Bim expression and caspase-3 and caspase-9 activation.
conclusionRUNX3 expression enhanced serum starvation-induced apoptosis in HCC cell lines. RUNX3 is deleted or weakly expressed in HCC, which leads to tumorigenesis by escaping apoptosis.
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