ArticleBehavioral and brain functions : BBF2011
Activity-dependent regulation of MHC class I expression in the developing primary visual cortex of the common marmoset monkey.
Article in Behavioral and brain functions : BBF, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 101 citations in OpenAlex.
- Glutamate Signaling and Neuroligin/Neurexin Adhesion Play Opposing Roles That Are Mediated by Major Histocompatibility Complex I Molecules in Cortical Synapse Formation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- HLA in Alzheimer's Disease: Genetic Association and Possible Pathogenic Roles.Neuromolecular medicine · 2020Review
- Assessing the Expression of Major Histocompatibility Complex Class I on Primary Murine Hippocampal Neurons by Flow Cytometry.Journal of visualized experiments : JoVE · 2020Article
- Immunoglobulin-Like Receptors and Their Impact on Wiring of Brain Synapses.Annual review of genetics · 2018Review
- An Ontology Systems Approach on Human Brain Expression and Metaproteomics.Frontiers in microbiology · 2018Article
- Expression and alternative splicing of classical and nonclassical MHCI genes in the hippocampus and neuromuscular junction.Molecular and cellular neurosciences · 2016Article
- Developmental expression and localization of MHC class I molecules in the human central nervous system.Experimental brain research · 2015Article
- Spatial-Temporal Expression of Non-classical MHC Class I Molecules in the C57 Mouse Brain.Neurochemical research · 2015Article
- Article
- Mapping the mosaic sequence of primate visual cortical development.Frontiers in neuroanatomy · 2015Article
- MHC class I limits hippocampal synapse density by inhibiting neuronal insulin receptor signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- NDRG2 as a marker protein for brain astrocytes.Cell and tissue research · 2014Article
- Major histocompatibility complex I in brain development and schizophrenia.Biological psychiatry · 2014Review
- A simpler primate brain: the visual system of the marmoset monkey.Frontiers in neural circuits · 2014Review
- MHCI requires MEF2 transcription factors to negatively regulate synapse density during development and in disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- The expression pattern of classical MHC class I molecules in the development of mouse central nervous system.Neurochemical research · 2013Article
- The expression patterns of MHC class I molecules in the developmental human visual system.Neurochemical research · 2013Article
- Major histocompatibility complex class I proteins in brain development and plasticity.Trends in neurosciences · 2012Review
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSeveral recent studies have highlighted the important role of immunity-related molecules in synaptic plasticity processes in the developing and adult mammalian brains. It has been suggested that neuronal MHCI (major histocompatibility complex class I) genes play a role in the refinement and pruning of synapses in the developing visual system. As a fast evolutionary rate may generate distinct properties of molecules in different mammalian species, we studied the expression of MHCI molecules in a nonhuman primate, the common marmoset monkey (Callithrix jacchus). METHODS AND
resultsAnalysis of expression levels of MHCI molecules in the developing visual cortex of the common marmoset monkeys revealed a distinct spatio-temporal pattern. High levels of expression were detected very early in postnatal development, at a stage when synaptogenesis takes place and ocular dominance columns are formed. To determine whether the expression of MHCI molecules is regulated by retinal activity, animals were subjected to monocular enucleation. Levels of MHCI heavy chain subunit transcripts in the visual cortex were found to be elevated in response to monocular enucleation. Furthermore, MHCI heavy chain immunoreactivity revealed a banded pattern in layer IV of the visual cortex in enucleated animals, which was not observed in control animals. This pattern of immunoreactivity indicated that higher expression levels were associated with retinal activity coming from the intact eye.
conclusionsThese data demonstrate that, in the nonhuman primate brain, expression of MHCI molecules is regulated by neuronal activity. Moreover, this study extends previous findings by suggesting a role for neuronal MHCI molecules during synaptogenesis in the visual cortex.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.