ArticleSource code for biology and medicine2011
Tools for efficient epistasis detection in genome-wide association study.
Article in Source code for biology and medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Ultrafast genome-wide scan for SNP-SNP interactions in common complex disease.Genome research · 2012Pooled it
- Ensemble survival tree models to reveal pairwise interactions of variables with time-to-events outcomes in low-dimensional setting.Statistical applications in genetics and molecular biology · 2018Article
- Genome-Wide Association Studies and Liver Disease.Seminars in liver disease · 2015Article
- Article
- An epistatic interaction between the PAX8 and STK17B genes in papillary thyroid cancer susceptibility.PloS one · 2013Article
- Current applications of models of genetic effects with interactions across the genome.Current genomics · 2012Article
- Performance analysis of novel methods for detecting epistasis.BMC bioinformatics · 2011Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundGenome-wide association study (GWAS) aims to find genetic factors underlying complex phenotypic traits, for which epistasis or gene-gene interaction detection is often preferred over single-locus approach. However, the computational burden has been a major hurdle to apply epistasis test in the genome-wide scale due to a large number of single nucleotide polymorphism (SNP) pairs to be tested.
resultsWe have developed a set of three efficient programs, FastANOVA, COE and TEAM, that support epistasis test in a variety of problem settings in GWAS. These programs utilize permutation test to properly control error rate such as family-wise error rate (FWER) and false discovery rate (FDR). They guarantee to find the optimal solutions, and significantly speed up the process of epistasis detection in GWAS.
conclusionsA web server with user interface and source codes are available at the website http://www.csbio.unc.edu/epistasis/. The source codes are also available at SourceForge http://sourceforge.net/projects/epistasis/.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.