ArticleBMC microbiology2011
Comparative genomic analysis reveals significant enrichment of mobile genetic elements and genes encoding surface structure-proteins in hospital-associated clonal complex 2 Enterococcus faecalis.
Article in BMC microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 54 citations in OpenAlex.
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- Genomic diversity, antibiotic resistance, and virulence in South African Enterococcus faecalis and Enterococcus lactis isolates.World journal of microbiology & biotechnology · 2024Article
- High Incidence of Multiple-Drug-Resistant Pheromone-Responsive Plasmids and Transmissions of VanA-Type Vancomycin-ResistantAntibiotics (Basel, Switzerland) · 2023Article
- DUF916 and DUF3324 in the WxL protein cluster bind to WxL and link bacterial and host surfaces.Protein science : a publication of the Protein Society · 2023Article
- Dissemination of Enterococcal Genetic Lineages: A One Health Perspective.Antibiotics (Basel, Switzerland) · 2023Review
- Bioinformatic analysis of WxL domain proteins.Saudi journal of biological sciences · 2023Article
- Extensive Comparative Genomic Analysis ofMicroorganisms · 2021Article
- Enterococcal Genetics.Microbiology spectrum · 2019Review
- Beneficial properties of lactic acid bacteria naturally present in dairy production.BMC microbiology · 2018Article
- Phage Therapy: What Have We Learned?Viruses · 2018Review
- Distribution of antimicrobial resistance determinants, virulence-associated factors and clustered regularly interspaced palindromic repeats loci in isolates of Enterococcus faecalis from various settings and genetic lineages.Pathogens and disease · 2017Article
- Assessment of virulence potential of uncharacterized Enterococcus faecalis strains using pan genomic approach - Identification of pathogen-specific and habitat-specific genes.Scientific reports · 2016Article
- Genome Modification in Enterococcus faecalis OG1RF Assessed by Bisulfite Sequencing and Single-Molecule Real-Time Sequencing.Journal of bacteriology · 2015Article
- A genomic virulence reference map of Enterococcus faecalis reveals an important contribution of phage03-like elements in nosocomial genetic lineages to pathogenicity in a Caenorhabditis elegans infection model.Infection and immunity · 2015Article
- Investigating the mobilome in clinically important lineages of Enterococcus faecium and Enterococcus faecalis.BMC genomics · 2015Article
- Comprehensive molecular, genomic and phenotypic analysis of a major clone of Enterococcus faecalis MLST ST40.BMC genomics · 2015Article
- Insyght: navigating amongst abundant homologues, syntenies and gene functional annotations in bacteria, it's that symbol!Nucleic acids research · 2014Article
- Friend turned foe: evolution of enterococcal virulence and antibiotic resistance.Annual review of microbiology · 2014Review
- Nonclinical and clinical Enterococcus faecium strains, but not Enterococcus faecalis strains, have distinct structural and functional genomic features.Applied and environmental microbiology · 2014Article
- In vivo assessment of growth and virulence gene expression during commensal and pathogenic lifestyles of luxABCDE-tagged Enterococcus faecalis strains in murine gastrointestinal and intravenous infection models.Applied and environmental microbiology · 2013Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEnterococci rank among the leading causes of nosocomial infections. The failure to identify pathogen-specific genes in Enterococcus faecalis has led to a hypothesis where the virulence of different strains may be linked to strain-specific genes, and where the combined endeavor of the different gene-sets result in the ability to cause infection. Population structure studies by multilocus sequence typing have defined distinct clonal complexes (CC) of E. faecalis enriched in hospitalized patients (CC2, CC9, CC28 and CC40).
resultsIn the present study, we have used a comparative genomic approach to investigate gene content in 63 E. faecalis strains, with a special focus on CC2. Statistical analysis using Fisher's exact test revealed 252 significantly enriched genes among CC2-strains. The majority of these genes were located within the previously defined mobile elements phage03 (n = 51), efaB5 (n = 34) and a vanB associated genomic island (n = 55). Moreover, a CC2-enriched genomic islet (EF3217 to -27), encoding a putative phage related element within the V583 genome, was identified. From the draft genomes of CC2-strains HH22 and TX0104, we also identified a CC2-enriched non-V583 locus associated with the E. faecalis pathogenicity island (PAI). Interestingly, surface related structures (including MSCRAMMs, internalin-like and WxL protein-coding genes) implicated in virulence were significantly overrepresented (9.1%; p = 0.036, Fisher's exact test) among the CC2-enriched genes.
conclusionIn conclusion, we have identified a set of genes with potential roles in adaptation or persistence in the hospital environment, and that might contribute to the ability of CC2 E. faecalis isolates to cause disease.
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