ArticleMolecular microbiology2011
Giardia lamblia low-density lipoprotein receptor-related protein is involved in selective lipoprotein endocytosis and parasite replication.
Article in Molecular microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 34 citations in OpenAlex.
- Endocytosis in anaerobic parasitic protists.Memorias do Instituto Oswaldo Cruz · 2024Review
- Combined nanometric and phylogenetic analysis of unique endocytic compartments in Giardia lamblia sheds light on the evolution of endocytosis in Metamonada.BMC biology · 2022Article
- A bloody interaction: plasma proteomics reveals gilthead sea bream (Sparus aurata) impairment caused by Sparicotyle chrysophrii.Parasites & vectors · 2022Article
- Lactoferrin and lactoferricin endocytosis halt Giardia cell growth and prevent infective cyst production.Scientific reports · 2018Article
- Membrane-Associated Proteins inGenes · 2018Review
- The invasive potential of Giardia intestinalis in an in vivo model.Scientific reports · 2015Article
- Parasites and their heterophagic appetite for disease.PLoS pathogens · 2015Review
- The genome of the myxosporean Thelohanellus kitauei shows adaptations to nutrient acquisition within its fish host.Genome biology and evolution · 2014Article
- Article
- The giardial VPS35 retromer subunit is necessary for multimeric complex assembly and interaction with the vacuolar protein sorting receptor.Biochimica et biophysica acta · 2013Article
- Receptor-mediated endocytosis and trafficking between endosomal-lysosomal vacuoles in Giardia lamblia.Parasitology research · 2013Article
- Lysosomal protein trafficking in Giardia lamblia: common and distinct features.Frontiers in bioscience (Elite edition) · 2012Review
- Vacuolar protein sorting receptor in Giardia lamblia.PloS one · 2012Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
As Giardia lamblia is unable to synthesize cholesterol de novo, this steroid might be obtained from the host's intestinal milieu by endocytosis of lipoproteins. In this work, we identified a putative Giardia lamblia low-density lipoprotein receptor-related proteins (GlLRP), a type I membrane protein, which shares the substrate N-terminal binding domain and a FXNPXY-type endocytic motif with human LRPs. Expression of tagged GlLRP showed that it was localized predominantly in the endoplasmic reticulum, lysosomal-like peripheral vacuoles and plasma membrane. However, the FXNPXY-deleted GlLRP was retained at the plasma membrane suggesting that it is abnormally transported and processed. The low-density lipoprotein and chylomicrons interacted with GlLRP, with this interaction being necessary for lipoprotein internalization and cell proliferation. Finally, we show that GlLRP binds directly to the medium subunit of Giardia adaptor protein 2, indicating that receptor-mediated internalization occurs through an adaptin mechanism.
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Registered trials
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