ArticleIndian journal of pediatrics2011
Immune Reconstitution Syndrome in HIV-1 infected children - a study from India.
Article in Indian journal of pediatrics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 3 of them syntheses that pooled it.
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Who cites it
7 citing papers in PubMed, 3 syntheses or guidelines pooled it, 13 citations in OpenAlex.
- Paediatric European Network for Treatment of AIDS (PENTA) guidelines for treatment of paediatric HIV-1 infection 2015: optimizing health in preparation for adult life.HIV medicine · 2018Guideline
- Tuberculosis Immune Reconstitution Inflammatory Syndrome in children initiating Antiretroviral Therapy for HIV infection: A systematic literature review.The Pediatric infectious disease journal · 2014Pooled it
- Guidelines for the prevention and treatment of opportunistic infections in HIV-exposed and HIV-infected children: recommendations from the National Institutes of Health, Centers for Disease Control and Prevention, the HIV Medicine Association of the Infectious Diseases Society of America, the Pediatric Infectious Diseases Society, and the American Academy of Pediatrics.The Pediatric infectious disease journal · 2013Guideline
- An Exclusively Skewed Distribution of Pediatric Immune Reconstitution Inflammatory Syndrome Toward the Female Sex Is Associated With Advanced Acquired Immune Deficiency Syndrome.Frontiers in pediatrics · 2019Article
- A prospective study of the immune reconstitution inflammatory syndrome (IRIS) in HIV-infected children from high prevalence countries.PloS one · 2019Observational
- Parasitic infections in HIV infected individuals: diagnostic & therapeutic challenges.The Indian journal of medical research · 2011Review
- Immune reconstitution syndrome in a human immunodeficiency virus infected child due to giardiasis leading to shock.Journal of family medicine and primary careArticle
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine incidence of Immune Reconstitutional Syndrome (IRIS) in HIV infected children and also to determine risk factors associated with it.
methodsThirty-seven HIV infected children who were started on Antiretroviral therapy (ART) in past 2 years were included in the study. Statistical Analysis was done using Chi Square test.
resultsSeven patients (18.9%) had IRIS at a mean interval of 1.7 ± 0.8 months. Two patients (28.6%) had tuberculosis (TB), 2 patient (28.6%) had herpes zoster and 1 patient (14.3%) each had pneumonia, toxoplasmosis and esophageal candidiasis. There was no significant difference as per age (p = 0.8), WHO Stage of disease (p = 0.93), Sex (0.45), type of antiretroviral regime (p = 0.38) and severity of immune suppression (0.98). It was found that patients with opportunistic infections (OIs) before treatment would have increased incidence of IRIS (p = 0.05). The mean OIs/year prior to treatment in patients with IRIS was 2.6 ± 1.4 vs. 1.7 ± 1.2.
conclusionsIncidence of IRIS in HIV infected children in Mumbai is 18.9%. Patients with OIs before treatment with ART have an increased incidence of IRIS. Clinical stage of disease or degree of immune suppression prior to treatment had no effect on incidence of IRIS.
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