ArticleEuropean journal of pediatrics2011
Management of pulmonary hypertension in Down syndrome.
Article in European journal of pediatrics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06043440 (Randomized Control Trial of Oxygen Therapy in Children and Adolescents With Down Syndrome and Obstructive Sleep Apnea), which is not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomized Control Trial of Oxygen Therapy in Children and Adolescents With Down Syndrome and Obstructive Sleep Apnea
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Tracheal anomalies associated with Down syndrome: A systematic review.Pediatric pulmonology · 2021Pooled it
- Efficacy and safety of oral sildenafil in children with Down syndrome and pulmonary hypertension.BMC cardiovascular disorders · 2017Trial
- Article
- Pulmonary hypertension in adults with congenital heart defects (ACHDs)-in light of the 2022 ESC PAH guidelines-part I: definition, epidemiology, classification, diagnostics, genetics, risk stratification and follow-up, gender aspects.Cardiovascular diagnosis and therapy · 2024Review
- Case report: Progressive pulmonary artery hypertension in a case of megalencephaly-capillary malformation syndrome.Frontiers in genetics · 2023Article
- Pulmonary Hypertension in the Population with Down Syndrome.Cardiology and therapy · 2022Review
- Prevalence of pulmonary hypertension among children with Down syndrome: A systematic review and meta-analysis.World journal of clinical pediatrics · 2021Article
- Late presentation of shunt lesions in Down syndrome patients: the importance of multidisciplinary assessment and lifelong follow-up.European heart journal. Case reports · 2021Article
- Congenital Heart Defect and Pulmonary Hypertension in Children With Down Syndrome: Clinical Profile Over Two Decades.Cureus · 2021Article
- New Molecular and Organelle Alterations Linked to Down Syndrome Heart Disease.Frontiers in genetics · 2021Review
- Review
- Longitudinal assessment of cardiac function in infants with Down's syndrome using novel echocardiography techniques - project protocol.HRB open research · 2020Article
- Relationship Between Pulmonary Arterial Resistance and Compliance in Patients with Down Syndrome.Pediatric cardiology · 2019Article
- Advanced therapies in patients with congenital heart disease-related pulmonary arterial hypertension: results from a long-term, single center, real-world follow-up.Internal and emergency medicine · 2015Article
- Refractory pulmonary hypertension following extremely preterm birth: paradoxical improvement in oxygenation after atrial septostomy.European journal of pediatrics · 2014Article
- The Robyn Barst Memorial Lecture: Differences between the fetal, newborn, and adult pulmonary circulations: relevance for age-specific therapies (2013 Grover Conference series).Pulmonary circulation · 2014Review
- Down syndrome masked by Marfan syndrome in a neonate.BMJ case reports · 2013Article
- Evolving management of pediatric pulmonary arterial hypertension: impact of phosphodiesterase inhibitors.Pediatric cardiology · 2013Review
- Abnormal microRNA expression in Ts65Dn hippocampus and whole blood: contributions to Down syndrome phenotypes.Developmental neuroscience · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledChildren with Down syndrome (DS) are at greater risk of pulmonary arterial hypertension (PAH) than the general population, partly due to upper airway obstruction and congenital heart disease. We wished to review our management of PAH and suggest a protocol for the systematic management of these children. Children with DS and PAH were included as referred for assessment from March 2005 to May 2010. Twenty-five patients (13 boys) met inclusion criteria. The median age was 385 days (range, 106 to 5,734); mean tricuspid regurgitation jet was 3.5 (range, 2.7-4.8) m/s. At cardiac catheterisation, mean pulmonary artery mean pressure was 26 mmHg (range, 12 to 46), and mean pulmonary vascular resistance (PVR) was 4.14 U.m² (range, 1.20 to 12.43) at baseline. PVR fell to a mean of 2.68 U.m² (range, 0.38 to 10.69) with 20 ppm inhaled nitric oxide and 100% oxygen. Respiratory assessment included polysomnography (18), bronchoscopy (16), showing malacia (eight), adenotonsillar hypertrophy (eight) and floppy aryepiglottic folds (four). One lung biopsy showed plexogenic arteriopathy, and one was diagnosed with tracheo-oesophageal fistula.
conclusionIn order to manage this complex group of patients, a combined cardiological, respiratory and surgical approach was required. A protocol with cardiac catheterisation, blood tests and respiratory assessment is suggested for the management of pulmonary hypertension in these children.
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