Trial reportMolecular medicine (Cambridge, Mass.)
Acute stress elicited by bungee jumping suppresses human innate immunity.
Trial report in Molecular medicine (Cambridge, Mass.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05144022 (Multi-level Molecular Profiling of High Acute Stress), which is not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Multi-level Molecular Profiling of High Acute Stress
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Pooled it
- Voluntary activation of the sympathetic nervous system and attenuation of the innate immune response in humans.Proceedings of the National Academy of Sciences of the United States of America · 2014Trial
- Endogenous glucocorticoids and human immunity: Time to revisit old dogmas.Seminars in immunology · 2025Review
- Profile of precipitating factors and its implication in 160 Indian patients with Moyamoya angiopathy.Journal of neurology · 2023Observational
- A narrative review on yoga: a potential intervention for augmenting immunomodulation and mental health in COVID-19.BMC complementary medicine and therapies · 2022Review
- The carotid body: A novel key player in neuroimmune interactions.Frontiers in immunology · 2022Review
- Understanding acute stress-mediated immunity in teleost fish.Fish and shellfish immunology reports · 2021Review
- Molecular evaluation of chronic restrain stress in mice model of non metastatic fibrosarcoma.Journal of molecular histology · 2020Article
- From Beef to Bees: High-Throughput Kinome Analysis to Understand Host Responses of Livestock Species to Infectious Diseases and Industry-Associated Stress.Frontiers in immunology · 2020Review
- Repeated Changes to the Gravitational Field Negatively Affect the Serum Concentration of Select Growth Factors and Cytokines.Frontiers in physiology · 2019Article
- Gravitational stress during parabolic flights reduces the number of circulating innate and adaptive leukocyte subsets in human blood.PloS one · 2018Article
- Study protocol for a randomized controlled trial to explore the effects of personalized lifestyle advices and tandem skydives on pleasure in anhedonic young adults.BMC psychiatry · 2016Article
- Qualitative Analysis of Emotions: Fear and Thrill.Frontiers in psychology · 2016Article
- Greater Heart Rate Responses to Acute Stress Are Associated with Better Post-Error Adjustment in Special Police Cadets.PloS one · 2016Article
- Bloodcurdling movies and measures of coagulation: Fear Factor crossover trial.BMJ (Clinical research ed.) · 2015Article
- Models and Methods to Investigate Acute Stress Responses in Cattle.Animals : an open access journal from MDPI · 2015Article
- Autoethnography helps analyse emotions.Frontiers in psychology · 2015Article
- Effects of helium and air inhalation on the innate and early adaptive immune system in healthy volunteers ex vivo.Journal of translational medicine · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although a relation between diminished human immunity and stress is well recognized both within the general public and the scientific literature, the molecular mechanisms by which stress alters immunity remain poorly understood. We explored a novel model for acute human stress involving volunteers performing a first-time bungee jump from an altitude of 60 m and exploited this model to characterize the effects of acute stress in the peripheral blood compartment. Twenty volunteers were included in the study; half of this group was pretreated for 3 d with the β-receptor blocking agent propranolol. Blood was drawn 2 h before, right before, immediately after and 2 h after the jump. Plasma catecholamine and cortisol levels increased significantly during jumping, which was accompanied by significantly reduced ex vivo inducibility of proinflammatory cytokines as well as activation of coagulation and vascular endothelium. Kinome profiles obtained from the peripheral blood leukocyte fraction contained a strong noncanonical glucocorticoid receptor signal transduction signature after jumping. In apparent agreement, jumping down-regulated Lck/Fyn and cellular innate immune effector function (phagocytosis). Pretreatment of volunteers with propranolol abolished the effects of jumping on coagulation and endothelial activation but left the inhibitory effects on innate immune function intact. Taken together, these results indicate that bungee jumping leads to a catecholamine-independent immune suppressive phenotype and implicate noncanonical glucocorticoid receptor signal transduction as a major pathway linking human stress to impaired functioning of the human innate immune system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.