ArticlePloS one2010
Bone marrow support of the heart in pressure overload is lost with aging.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Anti-Inflammatory and Anti-(Lymph)angiogenic Properties of an ABCB5+ Limbal Mesenchymal Stem Cell Population.International journal of molecular sciences · 2024Article
- Cardiac recovery from pressure overload is not altered by thyroid hormone status in old mice.Frontiers in endocrinology · 2024Article
- Assessment of Myocardial Diastolic Dysfunction as a Result of Myocardial Infarction and Extracellular Matrix Regulation Disorders in the Context of Mesenchymal Stem Cell Therapy.Journal of clinical medicine · 2022Review
- Loss of dynamic regulation of G protein-coupled receptor kinase 2 by nitric oxide leads to cardiovascular dysfunction with aging.American journal of physiology. Heart and circulatory physiology · 2020Article
- Engineering stem cell cardiac patch with microvascular features representative of native myocardium.Theranostics · 2019Article
- Aging alters the immunological response to ischemic stroke.Acta neuropathologica · 2018Article
- Aging is protective against pressure overload cardiomyopathy via adaptive extracellular matrix remodeling.American journal of cardiovascular disease · 2017Article
- Erection rehabilitation following prostatectomy--current strategies and future directions.Nature reviews. Urology · 2016Review
- Proangiogenic Features of Mesenchymal Stem Cells and Their Therapeutic Applications.Stem cells international · 2016Review
- Pathological Left Ventricular Hypertrophy and Stem Cells: Current Evidence and New Perspectives.Stem cells international · 2016Review
- Stimulating endogenous cardiac repair.Frontiers in cell and developmental biology · 2015Review
- Increased mobilization of mesenchymal stem cells in patients with essential hypertension: the effect of left ventricular hypertrophy.Journal of clinical hypertension (Greenwich, Conn.) · 2014Article
- Enhancing the efficacy of mesenchymal stem cell therapy.World journal of stem cells · 2014Review
- Article
- Preservation of myocardial structure is enhanced by pim-1 engineering of bone marrow cells.Circulation research · 2012Article
- Heterochronic parabiosis for the study of the effects of aging on stem cells and their niches.Cell cycle (Georgetown, Tex.) · 2012Review
- Intramuscular VEGF activates an SDF1-dependent progenitor cell cascade and an SDF1-independent muscle paracrine cascade for cardiac repair.American journal of physiology. Heart and circulatory physiology · 2011Article
- Youth is wasted on the young.Stem cell research & therapy · 2011Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
rationaleExogenous stem cell delivery is under investigation to prevent and treat cardiac dysfunction. It is less studied as to the extent endogenous bone marrow derived stem cells contribute to cardiac homeostais in response to stress and the affects of aging on this stress response.
objectiveTo determine the role of bone marrow (BM) derived stem cells on cardiac homeostasis in response to pressure overload (PO) and how this response is altered by aging. METHODS AND
resultsYoung (8 weeks) and old (>40 weeks) C57/b6 mice underwent homo- and heterochronic BM transplantation prior to transverse aortic constriction (TAC). We found that older BM is associated with decreased cardiac function following TAC. This decreased function is associated with decrease in BM cell engraftment, increased myocyte apoptosis, decreased myocyte hypertrophy, increased myocardial fibrosis and decreased cardiac function. Additionally, there is a decrease in activation of resident cells within the heart in response to PO in old mice. Interestingly, these effects are not due to alterations in vascular density or inflammation in response to PO or differences in ex vivo stem cell migration between young and old mice.
conclusionsBM derived stem cells are activated in response to cardiac PO, and the recruitment of BM derived cells are involved in cardiac myocyte hypertrophy and maintenance of function in response to PO which is lost with aging.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.