ArticlePloS one2010
Regulation of muscle satellite cell activation and chemotaxis by angiotensin II.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 47 citations in OpenAlex.
- Myoblast deactivation within engineered human skeletal muscle creates a transcriptionally heterogeneous population of quiescent satellite-like cells.Biomaterials · 2022Article
- Withaferin A and Ovarian Cancer Antagonistically Regulate Skeletal Muscle Mass.Frontiers in cell and developmental biology · 2021Article
- Covid-19 and the Renin Angiotensin System: Implications for the Older Adults.The journal of nutrition, health & aging · 2020Review
- Angiotensin-II Drives Human Satellite Cells Toward Hypertrophy and Myofibroblast Trans-Differentiation by Two Independent Pathways.International journal of molecular sciences · 2019Article
- ACE Inhibitors and Sarcopenia: Covering All the BASEs?Drugs & aging · 2016Article
- Impaired regeneration: A role for the muscle microenvironment in cancer cachexia.Seminars in cell & developmental biology · 2016Review
- THE RENIN-ANGIOTENSIN SYSTEM AND THE BIOLOGY OF SKELETAL MUSCLE: MECHANISMS OF MUSCLE WASTING IN CHRONIC DISEASE STATES.Transactions of the American Clinical and Climatological Association · 2016Article
- Mechanisms of Cachexia in Chronic Disease States.The American journal of the medical sciences · 2015Article
- Angiotensin II receptor blockade promotes repair of skeletal muscle through down-regulation of aging-promoting C1q expression.Scientific reports · 2015Article
- The renin-angiotensin system and prevention of age-related functional decline: where are we now?Age (Dordrecht, Netherlands) · 2015Review
- Satellite cells: regenerative mechanisms and applicability in muscular dystrophy.Stem cells international · 2015Review
- Dual roles of palladin protein in in vitro myogenesis: inhibition of early induction but promotion of myotube maturation.PloS one · 2015Article
- Angiotensin type 2 receptor signaling in satellite cells potentiates skeletal muscle regeneration.The Journal of biological chemistry · 2014Article
- In vitro myoblast motility models: investigating migration dynamics for the study of skeletal muscle repair.Journal of muscle research and cell motility · 2013Review
- Effects of dexamethasone on angiotensin II-induced changes of monolayer permeability and F-actin distribution in glomerular endothelial cells.Experimental and therapeutic medicine · 2013Article
- Molecular mechanisms and signaling pathways of angiotensin II-induced muscle wasting: potential therapeutic targets for cardiac cachexia.The international journal of biochemistry & cell biology · 2013Review
- Angiotensin II inhibits satellite cell proliferation and prevents skeletal muscle regeneration.The Journal of biological chemistry · 2013Article
- Molecular networks of human muscle adaptation to exercise and age.PLoS genetics · 2013Article
- The Hippo pathway member Yap plays a key role in influencing fate decisions in muscle satellite cells.Journal of cell science · 2012Article
- Exercise training and peripheral arterial disease.Comprehensive Physiology · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of angiotensin II (Ang II) in skeletal muscle is poorly understood. We report that pharmacological inhibition of Ang II signaling or ablation of the AT1a receptor significantly impaired skeletal muscle growth following myotrauma, in vivo, likely due to impaired satellite cell activation and chemotaxis. In vitro experiments demonstrated that Ang II treatment activated quiescent myoblasts as evidenced by the upregulation of myogenic regulatory factors, increased number of β-gal+, Myf5-LacZ myoblasts and the acquisition of cellular motility. Furthermore, exogenous treatment with Ang II significantly increased the chemotactic capacity of C2C12 and primary cells while AT1a(-/-) myoblasts demonstrated a severe impairment in basal migration and were not responsive to Ang II treatment. Additionally, Ang II interacted with myoblasts in a paracrine-mediated fashion as 4 h of cyclic mechanical stimulation resulted in Ang II-induced migration of cocultured myoblasts. Ang II-induced chemotaxis appeared to be regulated by multiple mechanisms including reorganization of the actin cytoskeleton and augmentation of MMP2 activity. Collectively, these results highlight a novel role for Ang II and ACE inhibitors in the regulation of skeletal muscle growth and satellite cell function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.