ArticlePloS one2010
Nicotinic receptor gene CHRNA4 interacts with processing load in attention.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 29 citations in OpenAlex.
- Cognitive Control, the Anterior Cingulate, and Nicotinic Receptors: A Case of Heterozygote Advantage.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Overdominant Effect of aThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Nicotinic α4β2 Cholinergic Receptor Influences on Dorsolateral Prefrontal Cortical Neuronal Firing during a Working Memory Task.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Modulation of nicotine effects on selective attention by DRD2 and CHRNA4 gene polymorphisms.Psychopharmacology · 2015Article
- Nicotine reduces distraction under low perceptual load.Psychopharmacology · 2015Article
- Association of a nicotinic receptor gene polymorphism with spontaneous eyeblink rates.Scientific reports · 2015Article
- Nicotinergic Modulation of Attention-Related Neural Activity Differentiates Polymorphisms of DRD2 and CHRNA4 Receptor Genes.PloS one · 2015Article
- Nicotinic acetylcholine receptors in attention circuitry: the role of layer VI neurons of prefrontal cortex.Cellular and molecular life sciences : CMLS · 2014Review
- A novel differential susceptibility gene: CHRNA4 and moderation of the effect of maltreatment on child personality.Journal of child psychology and psychiatry, and allied disciplines · 2013Article
- Nicotinic acetylcholine receptors in rat forebrain that bind ¹⁸F-nifene: relating PET imaging, autoradiography, and behavior.Synapse (New York, N.Y.) · 2012Article
- Nicotinic filtering of sensory processing in auditory cortex.Frontiers in behavioral neuroscience · 2012Article
- Executive Dysfunction in MCI: Subtype or Early Symptom.International journal of Alzheimer's disease · 2012Article
- The Imaging and Cognition Genetics Conference 2011, ICG 2011: A Meeting of Minds.Frontiers in neuroscience · 2012Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPharmacological studies suggest that cholinergic neurotransmission mediates increases in attentional effort in response to high processing load during attention demanding tasks [1]. METHODOLOGY/PRINCIPAL
findingsIn the present study we tested whether individual variation in CHRNA4, a gene coding for a subcomponent in α4β2 nicotinic receptors in the human brain, interacted with processing load in multiple-object tracking (MOT) and visual search (VS). We hypothesized that the impact of genotype would increase with greater processing load in the MOT task. Similarly, we predicted that genotype would influence performance under high but not low load in the VS task. Two hundred and two healthy persons (age range = 39-77, Mean = 57.5, SD = 9.4) performed the MOT task in which twelve identical circular objects moved about the display in an independent and unpredictable manner. Two to six objects were designated as targets and the remaining objects were distracters. The same observers also performed a visual search for a target letter (i.e. X or Z) presented together with five non-targets while ignoring centrally presented distracters (i.e. X, Z, or L). Targets differed from non-targets by a unique feature in the low load condition, whereas they shared features in the high load condition. CHRNA4 genotype interacted with processing load in both tasks. Homozygotes for the T allele (N = 62) had better tracking capacity in the MOT task and identified targets faster in the high load trials of the VS task.
conclusionThe results support the hypothesis that the cholinergic system modulates attentional effort, and that common genetic variation can be used to study the molecular biology of cognition.
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