ArticlePLoS genetics2010
A young Drosophila duplicate gene plays essential roles in spermatogenesis by regulating several Y-linked male fertility genes.
Article in PLoS genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 84 citations in OpenAlex.
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- An orphan gene is essential for efficient sperm entry into eggs in Drosophila melanogaster.Genetics · 2025Article
- In-depth investigation of genome to refine QTL positions for spontaneous sex-reversal in XX rainbow trout.PloS one · 2025Article
- An orphan gene is essential for efficient sperm entry into eggs inbioRxiv : the preprint server for biology · 2024Article
- Human-specific epigenomic states in spermatogenesis.Computational and structural biotechnology journal · 2024Article
- De Novo Genes.Annual review of genetics · 2024Review
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- An Orphan Gene Enhances Male Reproductive Success in Plutella xylostella.Molecular biology and evolution · 2024Article
- Structure and molecular basis of spermatid elongation in theOpen biology · 2023Review
- HP6/Umbrea is dispensable for viability and fertility, suggesting essentiality of newly evolved genes is rare.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- The nearly complete assembly of the Cercis chinensis genome and Fabaceae phylogenomic studies provide insights into new gene evolution.Plant communications · 2023Article
- Species-specific partial gene duplication in Arabidopsis thaliana evolved novel phenotypic effects on morphological traits under strong positive selection.The Plant cell · 2022Article
- Genomic Signatures of Sexual Selection on Pollen-Expressed Genes in Arabis alpina.Molecular biology and evolution · 2022Article
- Rapid Gene Evolution in an Ancient Post-transcriptional and Translational Regulatory System Compensates for Meiotic X Chromosomal Inactivation.Molecular biology and evolution · 2022Article
- Transcription Factors Drive Opposite Relationships between Gene Age and Tissue Specificity in Male and Female Drosophila Gonads.Molecular biology and evolution · 2021Article
- Evolution of genome structure in theGenome research · 2021Article
- Sex biased expression and co-expression networks in development, using the hymenopteran Nasonia vitripennis.PLoS genetics · 2020Article
- Article
- Rapid Evolution of Gained Essential Developmental Functions of a Young Gene via Interactions with Other Essential Genes.Molecular biology and evolution · 2019Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gene duplication is supposed to be the major source for genetic innovations. However, how a new duplicate gene acquires functions by integrating into a pathway and results in adaptively important phenotypes has remained largely unknown. Here, we investigated the biological roles and the underlying molecular mechanism of the young kep1 gene family in the Drosophila melanogaster species subgroup to understand the origin and evolution of new genes with new functions. Sequence and expression analysis demonstrates that one of the new duplicates, nsr (novel spermatogenesis regulator), exhibits positive selection signals and novel subcellular localization pattern. Targeted mutagenesis and whole-transcriptome sequencing analysis provide evidence that nsr is required for male reproduction associated with sperm individualization, coiling, and structural integrity of the sperm axoneme via regulation of several Y chromosome fertility genes post-transcriptionally. The absence of nsr-like expression pattern and the presence of the corresponding cis-regulatory elements of the parental gene kep1 in the pre-duplication species Drosophila yakuba indicate that kep1 might not be ancestrally required for male functions and that nsr possibly has experienced the neofunctionalization process, facilitated by changes of trans-regulatory repertories. These findings not only present a comprehensive picture about the evolution of a new duplicate gene but also show that recently originated duplicate genes can acquire multiple biological roles and establish novel functional pathways by regulating essential genes.
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