ArticlePloS one2010
ATL9, a RING zinc finger protein with E3 ubiquitin ligase activity implicated in chitin- and NADPH oxidase-mediated defense responses.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed.
- E3 ubiquitin ligases in plant defense: mechanisms and prospects for resistance breeding.Science China. Life sciences · 2026Review
- Constitutive and inducible oleoresin defenses share genetic architectures and mechanisms in Pinus taeda.The New phytologist · 2026Article
- AMF primes immune genes against Puccinia hordei (Brown rust) in Hordeum vulgare but does not reduce pathogen burden.FEMS microbiology letters · 2026Article
- Gene Mapping and Genetic Analysis of Maize Resistance to Stalk Rot.International journal of molecular sciences · 2025Article
- Genome-wide analysis of the RING-H2 E3 ubiquitin ligase SlATL family in tomato.Scientific reports · 2025Article
- Deciphering the mechanism of E3 ubiquitin ligases in plant responses to abiotic and biotic stresses and perspectives on PROTACs for crop resistance.Plant biotechnology journal · 2024Review
- Meta-QTL analysis and identification of candidate genes for multiple-traits associated with spot blotch resistance in bread wheat.Scientific reports · 2024Article
- The Auto-Regulation of ATL2 E3 Ubiquitin Ligase Plays an Important Role in the Immune Response againstInternational journal of molecular sciences · 2024Article
- Comprehensive Characterization of the C3HC4 RING Finger Gene Family in Potato (International journal of molecular sciences · 2024Article
- Glutathione Contribution in Interactions betweenInternational journal of molecular sciences · 2023Article
- Intertwined Roles of Reactive Oxygen Species and Salicylic Acid Signaling Are Crucial for the Plant Response to Biotic Stress.International journal of molecular sciences · 2022Review
- MTO1-RESPONDING DOWN 1 (MRD1) is a transcriptional target of OZF1 for promoting salicylic acid-mediated defense in Arabidopsis.Plant cell reports · 2022Article
- The calcium-dependent protein kinase CPK28 is targeted by the ubiquitin ligases ATL31 and ATL6 for proteasome-mediated degradation to fine-tune immune signaling in Arabidopsis.The Plant cell · 2022Article
- The E3 Ubiquitin Ligase ATL9 Affects Expression of Defense Related Genes, Cell Death and Callose Deposition in Response to Fungal Infection.Pathogens (Basel, Switzerland) · 2022Article
- Expression Patterns and Functional Analysis of 11 E3 Ubiquitin Ligase Genes in Rice.Frontiers in plant science · 2022Article
- The co-chaperone HOP3 participates in jasmonic acid signaling by regulating CORONATINE-INSENSITIVE 1 activity.Plant physiology · 2021Article
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- Evolutionary and Characteristic Analysis of RING-DUF1117 E3 Ubiquitin Ligase Genes inBiomolecules · 2021Article
- ZNF213 negatively controls triple negative breast cancer progression via Hippo/YAP signaling.Cancer science · 2021Article
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Authors and funding
7 authors.
Funding
Abstract
Pathogen associated molecular patterns (PAMPs) are signals detected by plants that activate basal defenses. One of these PAMPs is chitin, a carbohydrate present in the cell walls of fungi and in insect exoskeletons. Previous work has shown that chitin treatment of Arabidopsis thaliana induced defense-related genes in the absence of a pathogen and that the response was independent of the salicylic acid (SA), jasmonic acid (JA) and ethylene (ET) signaling pathways. One of these genes is ATL9 ( = ATL2G), which encodes a RING zinc-finger like protein. In the current work we demonstrate that ATL9 has E3 ubiquitin ligase activity and is localized to the endoplasmic reticulum. The expression pattern of ATL9 is positively correlated with basal defense responses against Golovinomyces cichoracearum, a biotrophic fungal pathogen. The basal levels of expression and the induction of ATL9 by chitin, in wild type plants, depends on the activity of NADPH oxidases suggesting that chitin-mediated defense response is NADPH oxidase dependent. Although ATL9 expression is not induced by treatment with known defense hormones (SA, JA or ET), full expression in response to chitin is compromised slightly in mutants where ET- or SA-dependent signaling is suppressed. Microarray analysis of the atl9 mutant revealed candidate genes that appear to act downstream of ATL9 in chitin-mediated defenses. These results hint at the complexity of chitin-mediated signaling and the potential interplay between elicitor-mediated signaling, signaling via known defense pathways and the oxidative burst.
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