ArticlePloS one2010
Uncertainty in the tail of the variant Creutzfeldt-Jakob disease epidemic in the UK.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 65 citations in OpenAlex.
- Estimating future variant Creutzfeldt-Jakob disease cases in the UK: a cohort-based probabilistic model.The Lancet regional health. Europe · 2025Article
- Assessing the risk of transfusion-transmitted variant Creutzfeldt-Jakob disease: a European perspective.Blood transfusion = Trasfusione del sangue · 2024Review
- Risk of variant Creutzfeldt-Jakob disease transmission by blood transfusion in Australia.Vox sanguinis · 2022Article
- Variant CJD: Reflections a Quarter of a Century on.Pathogens (Basel, Switzerland) · 2021Review
- The importance of ongoing international surveillance for Creutzfeldt-Jakob disease.Nature reviews. Neurology · 2021Review
- Article
- Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases.Nature neuroscience · 2018Review
- Diagnosis of Methionine/Valine Variant Creutzfeldt-Jakob Disease by Protein Misfolding Cyclic Amplification.Emerging infectious diseases · 2018Article
- Distribution and Quantitative Estimates of Variant Creutzfeldt-Jakob Disease Prions in Tissues of Clinical and Asymptomatic Patients.Emerging infectious diseases · 2017Article
- Sporadic and Infectious Human Prion Diseases.Cold Spring Harbor perspectives in medicine · 2017Review
- A case cluster of variant Creutzfeldt-Jakob disease linked to the Kingdom of Saudi Arabia.Brain : a journal of neurology · 2016Article
- Preclinical detection of infectivity and disease-specific PrP in blood throughout the incubation period of prion disease.Scientific reports · 2015Article
- Recent US Case of Variant Creutzfeldt-Jakob Disease-Global Implications.Emerging infectious diseases · 2015Article
- Preclinical detection of variant CJD and BSE prions in blood.PLoS pathogens · 2014Article
- Article
- Prevalent abnormal prion protein in human appendixes after bovine spongiform encephalopathy epizootic: large scale survey.BMJ (Clinical research ed.) · 2013Article
- Splice site SNPs of phospholipase PLCXD3 are significantly associated with variant and sporadic Creutzfeldt-Jakob disease.BMC medical genetics · 2013Article
- Prion infectivity in the spleen of a PRNP heterozygous individual with subclinical variant Creutzfeldt-Jakob disease.Brain : a journal of neurology · 2013Article
- Plasminogen-based capture combined with amplification technology for the detection of PrP(TSE) in the pre-clinical phase of infection.PloS one · 2013Article
- Empyema in spinal canal in thoracic region, abscesses in paravertebral space, spondylitis: in clinical course of zoonosis Erysipelothrix rhusiopathiae.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Despite low case numbers the variant Creutzfeldt-Jakob disease epidemic poses many challenges for public health planning due to remaining uncertainties in disease biology and transmission routes. We develop a stochastic model for variant CJD transmission, taking into account the known transmission routes (food and red-cell transfusion) to assess the remaining uncertainty in the epidemic. We use Bayesian methods to obtain scenarios consistent with current data. Our results show a potentially long but uncertain tail in the epidemic, with a peak annual incidence of around 11 cases, but the 95% credibility interval between 1 and 65 cases. These cases are predicted to be due to past food-borne transmissions occurring in previously mostly unaffected genotypes and to transmissions via blood transfusion in all genotypes. However, we also show that the latter are unlikely to be identifiable as transfusion-associated cases by case-linking. Regardless of the numbers of future cases, even in the absence of any further control measures, we do not find any self-sustaining epidemics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.