ArticleImmunology1990
Genetic influences on the immune repertoire following tuberculous infection in mice.
Article in Immunology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 43 citations in OpenAlex.
- The QTL within the H2 Complex Involved in the Control of Tuberculosis Infection in Mice Is the Classical Class II H2-Ab1 Gene.PLoS genetics · 2015Article
- Function and Potentials of M. tuberculosis Epitopes.Frontiers in immunology · 2014Review
- Lymphoproliferative response and its relationship with histological lesions in experimental ovine paratuberculosis and its diagnostic implications.Veterinary research communications · 2008Article
- Pulmonary immune responses to Propionibacterium acnes in C57BL/6 and BALB/c mice.American journal of respiratory cell and molecular biology · 2006Article
- Genetic architecture of tuberculosis resistance in a mouse model of infection.Genes and immunity · 2006Article
- The major histocompatibility complex haplotype affects T-cell recognition of mycobacterial antigens but not resistance to Mycobacterium tuberculosis in C3H mice.Infection and immunity · 2004Article
- Gamma interferon-producing CD4+ T lymphocytes in the lung correlate with resistance to infection with Mycobacterium tuberculosis.Infection and immunity · 2001Article
- Tuberculosis DNA vaccine encoding Ag85A is immunogenic and protective when administered by intramuscular needle injection but not by epidermal gene gun bombardment.Infection and immunity · 2000Article
- Capacity of murine T cells to retain long-term responsiveness to mycobacterial antigens is controlled by the H-2 complex.Clinical and experimental immunology · 1998Article
- B-cell epitopes and quantification of the ESAT-6 protein of Mycobacterium tuberculosis.Infection and immunity · 1998Article
- Three different putative phosphate transport receptors are encoded by the Mycobacterium tuberculosis genome and are present at the surface of Mycobacterium bovis BCG.Journal of bacteriology · 1997Article
- Influence of mouse strain and vaccine viability on T-cell responses induced by Mycobacterium bovis bacillus Calmette-Guérin.Infection and immunity · 1995Article
- Epitope specificity and isoforms of the mycobacterial 19-kilodalton antigen.Infection and immunity · 1994Article
- T-helper 1-like subset selection in Mycobacterium bovis bacillus Calmette-Guérin-infected resistant and susceptible mice.Immunology · 1994Article
- Distinct H-2 complex control of mortality, and immune responses to tuberculosis infection in virgin and BCG-vaccinated mice.Clinical and experimental immunology · 1993Article
- Impact of tuberculosis in children with idiopathic nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 1993Article
- Influence of genes from the major histocompatibility complex on the antibody repertoire against culture filtrate antigens in mice infected with live Mycobacterium bovis BCG.Infection and immunity · 1993Article
- Spleen cell cytokine secretion in Mycobacterium bovis BCG-infected mice.Infection and immunity · 1992Article
- Distinctive western blot antibody patterns induced by infection of mice with individual strains of the Mycobacterium avium complex.Immunology · 1992Article
- Influence of H-2 genes on growth of Mycobacterium tuberculosis in the lungs of chronically infected mice.Immunology · 1992Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Differences in the antibody repertoire between B10 and BALB background strains have been found following intraperitoneal infection of mice with Mycobacterium tuberculosis. Western blot analysis showed that B10 sera reacted with only a few antigenic bands, whereas BALB sera reacted with multiple bands, irrespective of the H-2 (b or k) haplotype. The oligo-banded pattern was a feature of live infection, since immunization with the mycobacterial extract in incomplete Freunds' adjuvant (IFA) produced a multi-banded response in both intact and in previously infected B10 mice. The multibanded BALB phenotype was dominantly expressed in (BALB x B10) F1 hybrids. The extent to which antibody levels to individual antigens varied was influenced by the combined effects of background (non-H-2) and H-2 genes: anti-65,000 molecular weight (MW) and anti-71,000 MW IgG levels were high in BALB but absent or low in B10 mice, irrespective of H-2 haplotypes, anti-19,000 MW levels in B10 mice were strongly H-2 controlled, whilst anti-38,000 MW levels were high in all tested strains. Immunoglobulin G1 (IgG1) subclass antibody and splenic interleukin-4 (IL-4) mRNA levels were distinctly lower in B10 than in BALB mice, but in vitro T-cell proliferative responses to mycobacterial antigens did not differ between the tested strains. It is proposed that the limited extracellular release of mycobacterial antigens required to stimulate B cells and/or differential activation of T-cell subsets may explain the narrow antibody repertoire in B10 strains of mice. This may have relevance to the outcome of infection, as bacterial counts were higher in the BALB strains at 10 weeks post-infection.
Indexed as
Identifiers
2120127PMC1384230W228649009What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.