ArticleMolecular psychiatry2012
Identification and functional characterization of three novel alleles for the serotonin transporter-linked polymorphic region.
Article in Molecular psychiatry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Association between 5-HT1A receptor C-1019G, 5-HTTLPR polymorphisms and panic disorder: a meta-analysis.Aging · 2024Pooled it
- Novel GxE effects and resilience: A case:control longitudinal study of psychosocial stress with war-affected youth.PloS one · 2022Trial
- Identification and functional characterization of the extremely long allele of the serotonin transporter-linked polymorphic region.Translational psychiatry · 2021Article
- Association of serotonin system-related genes with homicidal behavior and criminal aggression in a prison population of Pakistani Origin.Scientific reports · 2021Article
- TheFrontiers in genetics · 2021Article
- Promoter Activity-Based Case-Control Association Study on SLC6A4 Highlighting Hypermethylation and Altered Amygdala Volume in Male Patients With Schizophrenia.Schizophrenia bulletin · 2020Article
- Phased Haplotype Resolution of theGenes · 2020Article
- Neural and psychological characteristics of college students with alcoholic parents differ depending on current alcohol use.Progress in neuro-psychopharmacology & biological psychiatry · 2018Article
- Role of the 5-HTTLPR and SNP Promoter Polymorphisms on Serotonin Transporter Gene Expression: a Closer Look at Genetic Architecture and In Vitro Functional Studies of Common and Uncommon Allelic Variants.Molecular neurobiology · 2016Review
- Native American ancestry leads to complexity in 5-HTTLPR polymorphism association studies.Molecular psychiatry · 2015Article
- Psychological distress following marital separation interacts with a polymorphism in the serotonin transporter gene to predict cardiac vagal control in the laboratory.Psychophysiology · 2015Article
- From pharmacogenetics to pharmacogenomics: the way toward the personalization of antidepressant treatment.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2014Review
- Berberine and evodiamine influence serotonin transporter (5-HTT) expression via the 5-HTT-linked polymorphic region.The pharmacogenomics journal · 2012Article
- 5-HTTLPR and early childhood adversities moderate cognitive and emotional processing in adolescence.PloS one · 2012Article
- Simultaneous genotyping of multiple polymorphisms in human serotonin transporter gene and detection of novel allelic variants.Translational psychiatry · 2011Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A promoter polymorphism in the serotonin transporter gene (5-HTTLPR) has been reported to confer relative risk for phenotypes (depression/anxiety) and endophenotypes (amygdala reactivity). In this report, we identify and characterize three rare 5-HTTLPR alleles not previously described in the human literature. The three novel alleles were identified while genotyping 5-HTTLPR in a family-based attention deficit hyperactivity disorder clinical population. Two of the novel alleles are longer than the common 16-repeat long (L) allele (17 and 18 repeats) and the third is significantly smaller than the 14-repeat short (S) allele (11 repeats). The sequence and genetic architecture of each novel allele is described in detail. We report a significant decrease in the expression between the XL₁₇ (17r) allele and the L(A) (16r) allele. The XS₁₁ (11r) allele showed similar expression with the S (14r) allele. A 1.8-fold increase in expression was observed with the L(A)(16r) allele compared with the L(G) (16r) allele, which replicates results from earlier 5-HTTLPR expression experiments. In addition, transcription factor binding site (TFBS) analysis was performed using MatInspector (Genomatix) that showed the presence or absence of different putative TFBSs between the novel alleles and the common L (16r) and S (14r) alleles. The identification of rare variants and elucidation of their functional impact could potentially lead to understanding the contribution that the rare variant may have on the inheritance/susceptibility of multifactorial common diseases.
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