Trial reportMedicine and science in sports and exercise2011
Interhemispheric plasticity in humans.
Trial report in Medicine and science in sports and exercise, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
67 citing papers in PubMed, 2 syntheses or guidelines pooled it, 147 citations in OpenAlex.
- Non-local Acute Passive Stretching Effects on Range of Motion in Healthy Adults: A Systematic Review with Meta-analysis.Sports medicine (Auckland, N.Z.) · 2021Pooled it
- Cross-education of muscular strength following unilateral resistance training: a meta-analysis.European journal of applied physiology · 2017Pooled it
- Determining the cortical, corticospinal, and reticulospinal responses to metronome-paced and self-paced strength training.European journal of applied physiology · 2026Trial
- The decay and consolidation of effector-independent motor memories.Scientific reports · 2022Trial
- The ipsilateral corticospinal responses to cross-education are dependent upon the motor-training intervention.Experimental brain research · 2018Trial
- Unilateral strength training leads to muscle-specific sparing effects during opposite homologous limb immobilization.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Trial
- Adaptations in corticospinal excitability and inhibition are not spatially confined to the agonist muscle following strength training.European journal of applied physiology · 2017Trial
- Cross-education of muscular strength is facilitated by homeostatic plasticity.European journal of applied physiology · 2017Trial
- No evidence of neural adaptations following chronic unilateral isometric training of the intrinsic muscles of the hand: a randomized controlled study.European journal of applied physiology · 2016Trial
- Cross-education of wrist extensor strength is not influenced by non-dominant training in right-handers.European journal of applied physiology · 2016Trial
- The effects of whole-body vibration on the cross-transfer of strength.TheScientificWorldJournal · 2012Trial
- Temporal dynamics of ipsilateral corticospinal excitability during the motor learning process of a complex manual task.Experimental brain research · 2026Article
- Novel evidence of age-related cortical and subcortical constraints in cross-education.GeroScience · 2026Article
- Reliability of force production based on the sense of effort at different force levels.Experimental brain research · 2026Article
- Paretic Hand Beta Band Intermuscular Coherence Increases Following non-Paretic Hand Exercise to Task-Failure in Chronic Stroke.Restorative neurology and neuroscience · 2026Article
- Peer-reviewed by human experts: AI failed in key steps to generate a scoping review on the neural mechanisms of cross-education.European journal of applied physiology · 2026Article
- Time to Cross Paths: Neuroplasticity-Informed ACL Rehabilitation that Includes Cross-Education.Sports medicine - open · 2026Article
- Cross-Education of Strength: From Theory to Practice in Contemporary Sports Rehabilitation-A Narrative Review and Clinical Implications.Sports medicine - open · 2025Review
- Reticulospinal and corticospinal responses in long-term strength-trained and untrained adults.European journal of applied physiology · 2025Article
- The Influence of Transcranial Alternating Current Stimulation on the Excitability of the Unstimulated Contralateral Primary Motor Cortex.Brain sciences · 2025Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 6 institutions in 3 countries.
Funding
Abstract
introductionChronic unimanual motor practice increases the motor output not only in the trained but also in the nonexercised homologous muscle in the opposite limb. We examined the hypothesis that adaptations in motor cortical excitability of the nontrained primary motor cortex (iM1) and in interhemispheric inhibition from the trained to the nontrained M1 mediate this interlimb cross education.
methodsHealthy, young volunteers (n=12) performed 1000 submaximal voluntary contractions (MVC) of the right first dorsal interosseus (FDI) at 80% MVC during 20 sessions.
resultsTrained FDI's MVC increased 49.9%, and the untrained FDI's MVC increased 28.1%. Although corticospinal excitability in iM1, measured with transcranial magnetic stimulation (TMS) before and after every fifth session, increased 6% at rest, these changes, as those in intracortical inhibition and facilitation, did not correlate with cross education. When weak and strong TMS of iM1 were delivered on a background of a weak and strong muscle contraction, respectively, of the right FDI, excitability of iM1 increased dramatically after 20 sessions. Interhemispheric inhibition decreased 8.9% acutely within sessions and 30.9% chronically during 20 sessions and these chronic reductions progressively became more strongly associated with cross education. There were no changes in force or TMS measures in the trained group's left abductor minimi digiti and there were no changes in the nonexercising control group (n=8).
conclusionsThe findings provide the first evidence for plasticity of interhemispheric connections to mediate cross education produced by a simple motor task.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.