ReviewPlastic and reconstructive surgery2011
Hyperbaric oxygen: its mechanisms and efficacy.
Review in Plastic and reconstructive surgery, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03615755 (A Pilot Study of Short Duration Hyperbaric Oxygen Therapy to Improve HbA1c, Leukocyte, and Serum Creatinine in Patient With Diabetic Foot Ulcer Wagner 3-4), which is not on this map. Cited by 259 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Pilot Study of Short Duration Hyperbaric Oxygen Therapy to Improve HbA1c, Leukocyte, and Serum Creatinine in Patient With Diabetic Foot Ulcer Wagner 3-4
Who cites it
259 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Effects of hyperbaric oxygen therapy on bone, muscle, cartilage, tendon and ligaments in animal studies: a systematic review.BMC musculoskeletal disorders · 2026Pooled it
- Hyperbaric Oxygen as an Adjunct in the Treatment of Venous Ulcers: A Systematic Review.Vascular and endovascular surgery · 2023Pooled it
- The utilization of hyperbaric oxygenation therapy in hypospadias repair: a systematic review and meta-analysis.International urology and nephrology · 2022Pooled it
- Evidence-Supported HBO Therapy in Femoral Head Necrosis: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2021Pooled it
- Application of Topical Oxygen Therapy in Healing Dynamics of Diabetic Foot Ulcers - A Systematic Review.The review of diabetic studies : RDS · 2019Pooled it
- Hyperbaric Oxygen Therapy for Chronic Venous Leg Ulcers: A Prospective Randomised Controlled Trial.International wound journal · 2026Trial
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- Trial
- Hyperbaric Oxygen for Lower Limb Trauma (HOLLT): an international multi-centre randomised clinical trial.Diving and hyperbaric medicine · 2022Trial
- Trial
- Hyperbaric oxygen therapy to prevent central airway stenosis after lung transplantation.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2021Trial
- Hyperbaric oxygen but not hyperbaric air increases insulin sensitivity in men with type 2 diabetes mellitus.Diving and hyperbaric medicine · 2020Trial
- Trial
- Protective Effect of Hyperbaric Oxygen Therapy on Cognitive Function in Patients with Vascular Dementia.Cell transplantation · 2019Trial
- Early Recovery of Exercise-Related Muscular Injury by HBOT.BioMed research international · 2019Trial
- A Pilot Study of Short-Duration Hyperbaric Oxygen Therapy to Improve HbA1c, Leukocyte, and Serum Creatinine in Patients with Diabetic Foot Ulcer Wagner 3-4.TheScientificWorldJournal · 2018Trial
- Hyperbaric oxygen in the artificial intelligence era: integration and innovation.Medical gas research · 2027Review
- Perioperative hyperbaric oxygen therapy: mechanisms, evidence, and clinical application.Medical gas research · 2027Review
- Adjunctive hyperbaric oxygen therapy in high-risk oculoplastic reconstructions requiring graft-based surgery: a retrospective case series.International ophthalmology · 2026Article
- An Update on Post-Surgical Wound Healing Management and Lower-Cost Alternatives: A Narrative Review for Healthcare Providers.Health science reports · 2026Article
199 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
backgroundThis article outlines therapeutic mechanisms of hyperbaric oxygen therapy and reviews data on its efficacy for clinical problems seen by plastic and reconstructive surgeons.
methodsThe information in this review was obtained from the peer-reviewed medical literature.
resultsPrincipal mechanisms of hyperbaric oxygen are based on intracellular generation of reactive species of oxygen and nitrogen. Reactive species are recognized to play a central role in cell signal transduction cascades, and the discussion will focus on these pathways. Systematic reviews and randomized clinical trials support clinical use of hyperbaric oxygen for refractory diabetic wound-healing and radiation injuries; treatment of compromised flaps and grafts and ischemia-reperfusion disorders is supported by animal studies and a small number of clinical trials, but further studies are warranted.
conclusionsClinical and mechanistic data support use of hyperbaric oxygen for a variety of disorders. Further work is needed to clarify clinical utility for some disorders and to hone patient selection criteria to improve cost efficacy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.