ArticleCell adhesion & migration
Temporal changes in Hox gene expression accompany endothelial cell differentiation of embryonic stem cells.
Article in Cell adhesion & migration. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Review
- Article
- HOX genes in stem cells: Maintaining cellular identity and regulation of differentiation.Frontiers in cell and developmental biology · 2022Review
- Regulation of Hemogenic Endothelial Cell Development and Function.Annual review of physiology · 2021Review
- A Case of Identity:Cancers · 2019Review
- Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity.Cell stem cell · 2017Article
- Arterial endothelial methylome: differential DNA methylation in athero-susceptible disturbed flow regions in vivo.BMC genomics · 2015Article
- Role of Hox genes in stem cell differentiation.World journal of stem cells · 2015Review
- Emerging topic: flow-related epigenetic regulation of endothelial phenotype through DNA methylation.Vascular pharmacology · 2014Review
- MicroRNAs: modulators of cell identity, and their applications in tissue engineering.MicroRNA (Shariqah, United Arab Emirates) · 2014Review
- Zebrafish hoxd4a acts upstream of meis1.1 to direct vasculogenesis, angiogenesis and hematopoiesis.PloS one · 2013Article
- HOXA9 methylation by PRMT5 is essential for endothelial cell expression of leukocyte adhesion molecules.Molecular and cellular biology · 2012Article
- Isolation and expansion of endothelial progenitor cells derived from mouse embryonic stem cells.Methods in molecular biology (Clifton, N.J.) · 2012Article
- The dual roles of homeobox genes in vascularization and wound healing.Cell adhesion & migrationReview
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
In pluripotent embryonic stem cells (ESCs), expression of the Hox master regulatory transcription factors that play essential roles in organogenesis, angiogenesis, and maintenance of differentiated tissues, is globally suppressed. We investigated whether differentiation of endothelial cells (ECs) from mouse ESCs was accompanied by activation of distinct Hox gene expression profiles. Differentiation was observed within 3 days, as indicated by the appearance of cells expressing specific endothelial marker genes (Flk-1+ /VE-Cadherin+ ). Expression of HoxA3 and HoxD3, which drive adult endothelial cell invasion and angiogenesis, peaked at day 3 and declined thereafter, whereas expression of HoxA5 and HoxD10, which maintain a mature quiescent EC phenotype, was low at day 3, but increased over time. The temporal and reciprocal changes in HoxD3 and HoxA5 expression were accompanied by corresponding changes in expression of established downstream target genes including integrin β3 and Thrombospondin-2. Our results indicate that differentiation and maturation of ECs derived from cultured ESCs mimic changes in Hox gene expression that accompany maturation of immature angiogenic endothelium into differentiated quiescent endothelium in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.