ArticleProceedings of the National Academy of Sciences of the United States of America2011
Evolution of molecular error rates and the consequences for evolvability.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
- Human deleterious mutation rate slows adaptation and implies high fitness variance.bioRxiv : the preprint server for biology · 2025Article
- Genetic and selective constraints on the optimization of gene product diversity.bioRxiv : the preprint server for biology · 2024Article
- Article
- Fitness Effects of Phenotypic Mutations at Proteome-Scale Reveal Optimality of Translation Machinery.Molecular biology and evolution · 2024Article
- Investigating the Inhibition of FTSJ1, a Tryptophan tRNA-Specific 2'-O-Methyltransferase by NV TRIDs, as a Mechanism of Readthrough in Nonsense Mutated CFTR.International journal of molecular sciences · 2023Article
- Not Quite Lost in Translation: Mistranslation Alters Adaptive Landscape Topography and the Dynamics of Evolution.Molecular biology and evolution · 2023Article
- Gene product diversity: adaptive or not?Trends in genetics : TIG · 2022Review
- Phenotypic mutations contribute to protein diversity and shape protein evolution.Protein science : a publication of the Protein Society · 2022Review
- Random peptides rich in small and disorder-promoting amino acids are less likely to be harmful.Genome biology and evolution · 2022Article
- Non-Darwinian Molecular Biology.Frontiers in genetics · 2022Review
- Effective Population Size Predicts Local Rates but Not Local Mitigation of Read-through Errors.Molecular biology and evolution · 2021Article
- Stop codon read-through of mammalianThe Journal of biological chemistry · 2020Article
- Supersized Ribosomal RNA Expansion Segments in Asgard Archaea.Genome biology and evolution · 2020Article
- Readthrough Errors Purge Deleterious Cryptic Sequences, Facilitating the Birth of Coding Sequences.Molecular biology and evolution · 2020Article
- Global mistranslation increases cell survival under stress in Escherichia coli.PLoS genetics · 2020Article
- High Transcriptional Error Rates Vary as a Function of Gene Expression Level.Genome biology and evolution · 2020Article
- Let-7a-regulated translational readthrough of mammalian AGO1 generates a microRNA pathway inhibitor.The EMBO journal · 2019Article
- What viruses tell us about evolution and immunity: beyond Darwin?Annals of the New York Academy of Sciences · 2019Review
- De novo gene birth.PLoS genetics · 2019Article
- Stop-codon read-through arises largely from molecular errors and is generally nonadaptive.PLoS genetics · 2019Article
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Authors and funding
2 authors.
Funding
Abstract
Making genes into gene products is subject to predictable errors, each with a phenotypic effect that depends on a normally cryptic sequence. Many cryptic sequences have strongly deleterious effects, for example when they cause protein misfolding. Strongly deleterious effects can be avoided globally by avoiding making errors (e.g., via proofreading machinery) or locally by ensuring that each error has a relatively benign effect. The local solution requires powerful selection acting on every cryptic site and so evolves only in large populations. Small populations with less effective selection evolve global solutions. Here we show that for a large range of realistic intermediate population sizes, the evolutionary dynamics are bistable and either solution may result. The local solution facilitates the genetic assimilation of cryptic genetic variation and therefore substantially increases evolvability.
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