ArticleInfection and immunity2011
Genotype is correlated with but does not predict virulence of Vibrio vulnificus biotype 1 in subcutaneously inoculated, iron dextran-treated mice.
Article in Infection and immunity, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 62 citations in OpenAlex.
- Phylogeny-aware comparative genomics ofmBio · 2026Article
- Hybridization capture sequencing formBio · 2025Article
- Phylogenetic Characterization ofFoodborne pathogens and disease · 2025Article
- Genomic characteristics of Vibrio vulnificus strains isolated from clinical and environmental sources.Genomics & informatics · 2024Article
- Genomic Insight into Zoonotic and EnvironmentalMicroorganisms · 2024Article
- Antibiotic resistance trends amongApplied and environmental microbiology · 2024Article
- PandemicLife science alliance · 2023Article
- Environmental Reservoirs of Pathogenic Vibrio spp. and Their Role in Disease: The List Keeps Expanding.Advances in experimental medicine and biology · 2023Review
- Article
- Sewage Promotes Vibrio vulnificus Growth and Alters Gene Transcription in Vibrio vulnificus CMCP6.Microbiology spectrum · 2022Article
- Ecological diversification reveals routes of pathogen emergence in endemicProceedings of the National Academy of Sciences of the United States of America · 2021Article
- First report from Bangladesh on genetic diversity of multidrug-resistantVeterinary world · 2021Article
- Biochemical and Virulence Characterization ofFrontiers in cellular and infection microbiology · 2021Article
- Analysis of Gene Expression Profiles, Cytokines, and Bacterial Loads Relevant to Alcoholic Liver Disease Mice Infected WithFrontiers in immunology · 2021Article
- Exploring the Pathogenic Potential ofMicroorganisms · 2020Article
- Epidemiology, pathogenetic mechanism, clinical characteristics, and treatment of Vibrio vulnificus infection: a case report and literature review.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2019Review
- RRSP and RID Effector Domains Dominate the Virulence Impact of Vibrio vulnificus MARTX Toxin.The Journal of infectious diseases · 2019Article
- Whole-genome comparison between reference sequences and oyster Vibrio vulnificus C-genotype strains.PloS one · 2019Article
- Preliminary study on the antimicrobial susceptibility pattern related to the genotype ofItalian journal of food safety · 2017Article
- The Effector Domain Region of the Vibrio vulnificus MARTX Toxin Confers Biphasic Epithelial Barrier Disruption and Is Essential for Systemic Spread from the Intestine.PLoS pathogens · 2017Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Vibrio vulnificus is the leading cause of reported deaths from infections related to consumption of seafood in the United States. Affected predisposed individuals frequently die rapidly from sepsis. Otherwise healthy people can experience severe wound infection, which can lead to sepsis and death. A question is why, with so many people consuming contaminated raw oysters, the incidence of severe V. vulnificus disease is low. Molecular typing systems have shown associations of V. vulnificus genotypes and the environmental or clinical source of the strains, suggesting that different genotypes possess different virulence potentials. We examined 69 V. vulnificus biotype 1 strains that were genotyped by several methods and evaluated them for virulence in a subcutaneously inoculated iron dextran-treated mouse model. By examining the relationships between skin infection, systemic liver infection, and presumptive death (a decrease in body temperature), we determined that liver infection is predicated on severe skin infection and that death requires significant liver infection. Although most strains caused severe skin infection, not every strain caused systemic infection and death. Strains with polymorphisms at multiple loci (rrn, vcg, housekeeping genes, and repetitive DNA) designated profile 2 were more likely to cause lethal systemic infection with more severe indicators of virulence than were profile 1 strains with different polymorphisms at these loci. However, some profile 1 strains were lethal and some profile 2 strains did not cause systemic infection. Therefore, current genotyping schemes cannot strictly predict the virulence of V. vulnificus strains and further investigation is needed to identify virulence genes as markers of virulence.
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