ArticleJournal of immunology (Baltimore, Md. : 1950)2011
IFN-γ attenuates hypoxia-inducible factor (HIF) activity in intestinal epithelial cells through transcriptional repression of HIF-1β.
Article in Journal of immunology (Baltimore, Md. : 1950), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- Trial
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- Review
- Identification and cross-validation of autophagy-related genes in cardioembolic stroke.Frontiers in neurology · 2023Article
- Blood flow restriction in human skeletal muscle during rest periods after high-load resistance training down-regulates miR-206 and induces Pax7.Journal of sport and health science · 2021Article
- How Viral and Intracellular Bacterial Pathogens Reprogram the Metabolism of Host Cells to Allow Their Intracellular Replication.Frontiers in cellular and infection microbiology · 2019Review
- HIF-dependent regulation of claudin-1 is central to intestinal epithelial tight junction integrity.Molecular biology of the cell · 2015Article
- Metabolic regulation of intestinal epithelial barrier during inflammation.Tissue barriers · 2015Article
- Interferon-γ suppresses intestinal epithelial aquaporin-1 expression via Janus kinase and STAT3 activation.PloS one · 2015Article
- IFN-γ-mediated induction of an apical IL-10 receptor on polarized intestinal epithelia.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Hypoxia and Integrin-Mediated Epithelial Restitution during Mucosal Inflammation.Frontiers in immunology · 2013Review
- Netrin-1 guides inflammatory cell migration to control mucosal immune responses during intestinal inflammation.Tissue barriers · 2013Article
- Hypoxia and hypoxia-inducible factors as regulators of T cell development, differentiation, and function.Immunologic research · 2013Review
- Priming effect of aspirin for tumor cells to augment cytotoxic action of cisplatin against tumor cells: implication of altered constitution of tumor microenvironment, expression of cell cycle, apoptosis, and survival regulatory molecules.Molecular and cellular biochemistry · 2012Article
- Role of RhoA and its effectors ROCK and mDia1 in the modulation of deformation-induced FAK, ERK, p38, and MLC motogenic signals in human Caco-2 intestinal epithelial cells.American journal of physiology. Cell physiology · 2011Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Numerous studies have revealed that hypoxia and inflammation occur coincidentally in mucosal disorders, such as inflammatory bowel disease. During inflammation, epithelial-expressed hypoxia-inducible factor (HIF) serves an endogenously protective function. In this study, we sought to explore how mucosal immune responses influence HIF-dependent end points. Guided by a screen of relevant inflammatory mediators, we identified IFN-γ as a potent repressor of HIF-dependent transcription in human intestinal epithelial cells. Analysis of HIF levels revealed that HIF-1β, but not HIF-1α, is selectively repressed by IFN-γ in a JAK-dependent manner. Cloning and functional analysis of the HIF-1β promoter identified a prominent region for IFN-γ-dependent repression. Further studies revealed that colonic IFN-γ and HIF-1β levels were inversely correlated in a murine colitis model. Taken together, these studies demonstrated that intestinal epithelial HIF is attenuated by IFN-γ through transcriptional repression of HIF-1β. These observations are relevant to the pathophysiology of colitis (i.e., that loss of HIF signaling during active inflammation may exacerbate disease pathogenesis).
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Registered trials
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