Evidence map›Paper›PMID 21199783›Full record

ReviewInternational review of cell and molecular biology2011

The biology of the desmosome-like junction a versatile anchoring junction and signal transducer in the seminiferous epithelium.

Pearl P Y Lie, C Yan Cheng, Dolores D Mruk

Abstract readReview
In one paragraph

Review in International review of cell and molecular biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
188.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 71 citations in OpenAlex.

  1. Establishment of Sertoli Cell Lines from Giant Pandas (Animals : an open access journal from MDPI · 2026
    Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Drug transport across the blood-testis barrier.American journal of translational research · 2022
    Review
  13. Article
  14. Article
  15. Review
  16. Motor Proteins and Spermatogenesis.Advances in experimental medicine and biology · 2021
    Review
  17. Microtubule Cytoskeleton and Spermatogenesis-Lesson From Studies of Toxicant Models.Toxicological sciences : an official journal of the Society of Toxicology · 2020
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Pearl P Y LiePopulation Council, Center for Biomedical Research, New York, New York, USA.
C Yan Cheng
Dolores D Mruk
Population Council · US

Funding

SPECIALIZED CONTRACEPTIVE DEVELOPMENT RESEARCH CENTERU54HD029990 · NICHD · POPULATION COUNCIL · PI KUMAR, NARENDER · 1992 to 2016
$27.7M
The biology of blood-testis barrier dynamicsR01HD056034 · NICHD · POPULATION COUNCIL · PI CHENG, C. YAN · 2009 to 2018
$3.4M
Biology of desmosome-gap junctions in the testisR03HD061401 · NICHD · POPULATION COUNCIL · PI MRUK, DOLORES D · 2009 to 2010
$160k
An in vivo model to study blood-testis barrier dynamicsR03HD051512 · NICHD · POPULATION COUNCIL · PI CHENG, C. YAN · 2007 to 2008
$143k
NICHD NIH HHS R01 HD056034NICHD NIH HHS R01HD056034NICHD NIH HHS R03 HD051512NICHD NIH HHS R03HD051512NICHD NIH HHS R03 HD061401NICHD NIH HHS R03HD061401-01NICHD NIH HHS U54 HD029990NICHD NIH HHS U54HD029990
6 · The paper itself

Abstract

Mammalian spermatogenesis, a complex process that involves the movement of developing germ cells across the seminiferous epithelium, entails extensive restructuring of Sertoli-Sertoli and Sertoli-germ cell junctions. Presently, it is not entirely clear how zygotene spermatocytes gain entry into the adluminal compartment of the seminiferous epithelium, which is sealed off from the systemic circulation by the Sertoli cell component of the blood-testis barrier, without compromising barrier integrity. To begin to address this question, it is critical that we first have a good understanding of the biology and the regulation of different types of Sertoli-Sertoli and Sertoli-germ cell junctions in the testis. Supported by recent studies in the field, we discuss how crosstalk between different types of junctions contributes to their restructuring during germ cell movement across the blood-testis barrier. We place special emphasis on the emerging role of desmosome-like junctions as signal transducers during germ cell movement across the seminiferous epithelium.

Indexed as

Signal TransductionAdherens JunctionsAnimalsDesmosomesGerm CellsHumansIntercellular JunctionsMaleSeminiferous EpitheliumSertoli Cells

Identifiers

PMID21199783
PMCPMC4381909
OpenAlexW1517625476

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.