ReviewProgress in molecular biology and translational science2011
Role of the serotonergic system in alcohol dependence: from animal models to clinics.
Review in Progress in molecular biology and translational science, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 92 citations in OpenAlex.
- Sex Differences in Tryptophan Metabolism: A Systematic Review Focused on Neuropsychiatric Disorders.International journal of molecular sciences · 2023Pooled it
- Systemic Interplay of BDNF and Serotonin Pathways Defines Behavioral and Molecular Responses to Midbrain 5-HT7 Overexpression and Chronic Ethanol Consumption.Biomolecules · 2026Article
- Serotonin and neurofilament light chain in alcohol-related suicide: Preliminary case observations.Brain, behavior, & immunity - health · 2025Article
- Genetic liability for anxiety and treatment response to the monoamine stabilizer OSU6162 in alcohol dependence: a retrospective secondary analysis.Pharmacological reports : PR · 2025Article
- Exploring the effects of adolescent social isolation stress on the serotonin system and ethanol-motivated behaviors.Psychopharmacology · 2025Article
- Alcohol and alcoholism associated neurological disorders: Current updates in a global perspective and recent recommendations.World journal of experimental medicine · 2025Review
- Regulator of G protein signaling 6 (RGS6) in dopamine neurons promotes EtOH seeking, behavioral reward, and susceptibility to relapse.Psychopharmacology · 2024Article
- Exploring the association between melatonin and nicotine dependence (Review).International journal of molecular medicine · 2024Review
- Sex differences in neural networks recruited by frontloaded binge alcohol drinking.Addiction biology · 2024Article
- Associations of Changes in Alcohol Consumption on the Risk of Depression/Suicide Among Initial Nondrinkers.Depression and anxiety · 2024Article
- Article
- GDNF gene therapy for alcohol use disorder in male non-human primates.Nature medicine · 2023Article
- Alcohol and cannabinoid binges and daily exposure to nicotine in adolescent/young adult rats induce sex-dependent long-term appetitive instrumental learning impairment.Frontiers in behavioral neuroscience · 2023Article
- The regulatory role of AP-2β in monoaminergic neurotransmitter systems: insights on its signalling pathway, linked disorders and theragnostic potential.Cell & bioscience · 2022Review
- Associations between classic psychedelics and nicotine dependence in a nationally representative sample.Scientific reports · 2022Article
- The Combination of Galanin (1-15) and Escitalopram in Rats Suggests a New Strategy for Alcohol Use Disorder Comorbidity with Depression.Biomedicines · 2022Article
- Prolonged ethanol exposure modulates constitutive internalization and recycling of 5-HT1A receptors.Journal of neurochemistry · 2022Article
- Probiotics-Based Treatment as an Integral Approach for Alcohol Use Disorder in Alcoholic Liver Disease.Frontiers in pharmacology · 2021Review
- Receptors and Channels Associated with Alcohol Use: Contributions fromNeuroscience insights · 2021Review
- Early postnatal allopregnanolone levels alteration and adult behavioral disruption in rats: Implication for drug abuse.Neurobiology of stress · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Alcohol dependence remains among the most common substance abuse problems worldwide, and compulsive alcohol consumption is a significant public health concern. Alcohol is an addictive drug that alters brain function through interactions with multiple neurotransmitter systems. These neurotransmitter systems mediate the reinforcing effects of alcohol. Specifically, the serotonergic system is important in mediating alcohol reward, preference, dependence, and craving. In this review chapter, we first discuss the serotonin system as it relates to alcoholism, and then outline interactions between this system and other neurotransmitter systems. We emphasize the serotonin transporter and its possible role in alcoholism, then present several serotonergic receptors and discuss their contribution to alcoholism, and finally assess the serotonin system as a target for pharmacotherapy, with an emphasis on current and potential treatments.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.