ArticleBMC psychiatry2011
Markers of thrombogenesis are activated in unmedicated patients with acute psychosis: a matched case control study.
Article in BMC psychiatry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 74 citations in OpenAlex.
- Causal relationship between mental illness and venous thromboembolism: a Mendelian randomization study.European archives of psychiatry and clinical neuroscience · 2026Article
- Case Report: Early onset pulmonary embolism following antipsychotic polypharmacy in an acute psychiatric setting.Frontiers in psychiatry · 2026Article
- Body fluid biomarkers and psychosis risk in The Accelerating Medicines Partnership® Schizophrenia Program: design considerations.Schizophrenia (Heidelberg, Germany) · 2025Article
- The Influence of Multiple Modifiable Risk Factors on 30-day Readmissions and 90-day Major Complications After a Total Hip and Knee Arthroplasty: An Analysis of a Large Claims Database.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2025Article
- Blood-Brain Barrier Disruption in Schizophrenia: Insights, Mechanisms, and Future Directions.International journal of molecular sciences · 2025Review
- Olanzapine-Induced Acute Pulmonary Embolism.Cureus · 2024Article
- Sex-specific differences in the clinical profile among psychiatric patients with pulmonary Embolism: a hospital-based retrospective study.BMC pulmonary medicine · 2024Article
- Hypercoagulable state in patients with schizophrenia: different effects of acute and chronic antipsychotic medications.Therapeutic advances in psychopharmacology · 2023Article
- Plasma Soluble P-selectin, Interleukin-6 and S100B Protein in Patients with Schizophrenia: a Pilot Study.The Psychiatric quarterly · 2022Article
- Novel approaches in schizophrenia-from risk factors and hypotheses to novel drug targets.World journal of psychiatry · 2021Review
- Central retinal vein occlusion in a patient using the antipsychotic drug olanzapine: a case report.Journal of medical case reports · 2021Article
- Interactions of Antibodies to the Gram-Negative Gastric Bacterium Helicobacter pylori with the Synaptic Calcium Sensor Synaptotagmin 5, Correlate to Impaired Vesicle Recycling in SiMa Human Neuroblastoma Cells.Journal of molecular neuroscience : MN · 2021Article
- Reduced levels of circulating adhesion molecules in adolescents with early-onset psychosis.NPJ schizophrenia · 2020Article
- Plasma soluble P-selectin correlates with triglycerides and nitrite in overweight/obese patients with schizophrenia.Pteridines · 2020Article
- The difference in serum proteomes in schizophrenia and bipolar disorder.BMC genomics · 2019Article
- Risk of Upper Gastrointestinal Bleeding and Gastroduodenal Ulcers in Persons With Schizophrenia: A Danish Cohort Study.Clinical and translational gastroenterology · 2019Article
- Venous Thromboembolism as an Adverse Effect During Treatment With Olanzapine: A Case Series.Frontiers in psychiatry · 2019Article
- Blood-Based Protein Changes in Childhood Are Associated With Increased Risk for Later Psychotic Disorder: Evidence From a Nested Case-Control Study of the ALSPAC Longitudinal Birth Cohort.Schizophrenia bulletin · 2018Article
- Constructing the Immune Signature of Schizophrenia for Clinical Use and Research; An Integrative Review Translating Descriptives Into Diagnostics.Frontiers in psychiatry · 2018Review
- Venous Thromboembolism During Treatment with Antipsychotics: A Review of Current Evidence.CNS drugs · 2018Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAntipsychotic treatment has been repeatedly found to be associated with an increased risk for venous thromboembolism in schizophrenia. The extent to which the propensity for venous thromboembolism is linked to antipsychotic medication alone or psychosis itself is unclear. The objective of this study was to determine whether markers of thrombogenesis are increased in psychotic patients who have not yet been treated with antipsychotic medication.
methodsWe investigated the plasma levels of markers indicating activation of coagulation (D-dimers and Factor VIII) and platelets (soluble P-selectin, sP-selectin) in an antipsychotic-naive group of fourteen men and eleven women with acute psychosis (age 29.1 ± 8.3 years, body mass index 23.6 ± 4.7), and twenty-five healthy volunteers were matched for age, gender and body mass index.
resultsD-dimers (median 0.38 versus 0.19 mg/l, mean 1.12 ± 2.38 versus 0.28 ± 0.3 mg/l; P = 0.003) and sP-selectin (median 204.1 versus 112.4 ng/ml, mean 209.9 ± 124 versus 124.1 ± 32; P = 0.0005) plasma levels were significantly increased in the group of patients with acute psychosis as compared with healthy volunteers. We found a trend (median 148% versus 110%, mean 160 ± 72.5 versus 123 ± 62.5; P = 0.062) of increased plasma levels of factor VIII in psychotic patients as compared with healthy volunteers.
conclusionsThe results suggest that at least a part of venous thromboembolic events in patients with acute psychosis may be induced by pathogenic mechanisms related to psychosis rather than by antipsychotic treatment. Finding an exact cause for venous thromboembolism in psychotic patients is necessary for its effective treatment and prevention.
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