ArticlePediatric transplantation2011
Acute rejection associated with donor-specific anti-MICA antibody in a highly sensitized pediatric renal transplant recipient.
Article in Pediatric transplantation, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Non-HLA Antibodies in Kidney Transplantation: Immunity and Genetic Insights.Biomedicines · 2022Review
- Role of Anti-MICA Antibodies in Graft Survival of Renal Transplant Recipients of India.Journal of immunology research · 2018Article
- Endothelial Cells in Antibody-Mediated Rejection of Kidney Transplantation: Pathogenesis Mechanisms and Therapeutic Implications.Journal of immunology research · 2017Review
- MICA and NKG2D: Is There an Impact on Kidney Transplant Outcome?Frontiers in immunology · 2017Review
- Major Histocompatibility Complex Class I Chain-Related A (MICA) Molecules: Relevance in Solid Organ Transplantation.Frontiers in immunology · 2017Review
- Management of sensitized pediatric patients prior to renal transplantation.Pediatric nephrology (Berlin, Germany) · 2016Article
- Advances in diagnostics for transplant rejection.Expert review of molecular diagnostics · 2016Review
- Antibody Subclass Repertoire and Graft Outcome Following Solid Organ Transplantation.Frontiers in immunology · 2016Review
- Vascular endothelium as a target of immune response in renal transplant rejection.Frontiers in immunology · 2014Review
- Moving beyond HLA: a review of nHLA antibodies in organ transplantation.Human immunology · 2013Review
- Luminex and antibody detection in kidney transplantation.Clinical and experimental nephrology · 2012Review
- Immune responses to self-antigens (autoimmunity) in allograft rejection.Clinical transplants · 2012Article
- MHC Class I Related Chain A (MICA) Antibodies - A Potential Cause of Renal Allograft Rejection.Indian journal of nephrologyArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Allograft rejection in HLA identical transplant recipients and in patients without detectable donor-specific anti-HLA antibodies has lead to the identification of non-HLA antigens as targets of the alloimmune response. MICA antigen has been recognized as an important non-HLA target in renal transplantation. Recent studies have shown that anti-MICA antibodies are associated with acute renal allograft rejection and failure. Current cross match procedures using donor lymphocytes fail to detect MICA antibodies. Transplant candidates are not routinely tested for pre-sensitization to MICA antigens nor are transplant donors typed for MICA alleles. Optimal classification and treatment of acute rejection associated with MICA antibody remains unknown. In this case report, we are the first to describe the clinical course and treatment of donor-specific MICA antibody associated with both Banff type II A ACR and AMR in a highly sensitized pediatric renal re-transplant recipient. This case also emphasizes the importance of pre-transplant screening for donor-specific MICA antibody especially in highly sensitized renal transplant patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.