ArticleCell proliferation2011
MicroRNA signatures associated with immortalization of EBV-transformed lymphoblastoid cell lines and their clinical traits.
Article in Cell proliferation, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- Transcriptomics and miRNomics data integration in lymphoblastoid cells highlights the key role of immune-related functions in lithium treatment response in Bipolar disorder.BMC psychiatry · 2022Article
- Differential expression analysis comparing EBV uninfected to infected human cell lines identifies induced non-micro small non-coding RNAs.Non-coding RNA research · 2020Article
- SARM1 deficiency up-regulates XAF1, promotes neuronal apoptosis, and accelerates prion disease.The Journal of experimental medicine · 2019Article
- Identification of novel circulatory microRNA signatures linked to patients with ischemic stroke.Human molecular genetics · 2018Article
- Brief introduction of current technologies in isolation of broadly neutralizing HIV-1 antibodies.Virus research · 2018Review
- Genetics and Molecular Biology of Epstein-Barr Virus-Encoded BART MicroRNA: A Paradigm for Viral Modulation of Host Immune Response Genes and Genome Stability.Journal of immunology research · 2017Review
- miR-1296-5p decreases ERBB2 expression to inhibit the cell proliferation in ERBB2-positive breast cancer.Cancer cell international · 2017Article
- Prognostic value of 5-microRNA based signature in T2-T3N0 colon cancer.Clinical & experimental metastasis · 2016Article
- G protein-coupled receptor GPR160 is associated with apoptosis and cell cycle arrest of prostate cancer cells.Oncotarget · 2016Article
- The roles of microRNAs in Wilms' tumors.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Review
- MicroRNA-541 promotes the proliferation of vascular smooth muscle cells by targeting IRF7.American journal of translational research · 2016Article
- Review
- STAT1: A Novel Target of miR-150 and miR-223 Is Involved in the Proliferation of HTLV-I-Transformed and ATL Cells.Neoplasia (New York, N.Y.) · 2015Article
- MiR-144 Inhibits Uveal Melanoma Cell Proliferation and Invasion by Regulating c-Met Expression.PloS one · 2015Article
- Up-Regulation of MiR-300 Promotes Proliferation and Invasion of Osteosarcoma by Targeting BRD7.PloS one · 2015Article
- Article
- The downregulation of PRDM1/Blimp-1 is associated with aberrant expression of miR-223 in extranodal NK/T-cell lymphoma, nasal type.Journal of experimental & clinical cancer research : CR · 2014Article
- National Biobank of Korea: Quality control Programs of Collected-human Biospecimens.Osong public health and research perspectives · 2012Article
- Expression of BamHI-A Rightward Transcripts in Epstein-Barr Virus-Associated Gastric Cancers.Cancer research and treatment · 2011Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveMicroRNAs (miRNAs) are negative regulators of gene expression that play important roles in cell processes such as proliferation, development and differentiation. Recently, it has been reported that miRNAs are related to development of carcinogenesis. The aim of this study was to identify miRNAs associated with terminal immortalization of Epstein-Barr virus (EBV)-transformed lymphoblastoid cell line (LCL) and associated clinical traits. MATERIAL AND
methodsHence, we performed miRNA microarray approach with early- (p6) and late-passage (p161) LCLs. RESULTS AND
conclusionMicroarray data showed that nine miRNAs (miR-20b*, miR-28-5p, miR-99a, miR-125b, miR-151-3p, miR-151:9.1, miR-216a, miR-223* and miR-1296) were differentially expressed in most LCLs during long-term culture. In particular, miR-125b was up-regulated in all the tested late-passage LCLs. miR-99a, miR-125b, miR-216a and miR-1296 were putative negative regulators of RASGRP3, GPR160, PRKCH and XAF1, respectively, which were found to be differentially expressed in LCLs during long-term culture in a previous study. Linear regression analysis showed that miR-200a and miR-296-3p correlated with triglyceride and HbA1C levels, respectively, suggesting that miRNA signatures of LCLs could provide information on the donor's health. In conclusion, our study suggests that expression changes of specific miRNAs may be required for terminal immortalization of LCLs. Thus, differentially expressed miRNAs would be a potential marker for completion of cell immortalization during EBV-mediated tumorigenesis.
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Registered trials
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