ArticleThe European journal of neuroscience2011
Nucleus accumbens neurons encode predicted and ongoing reward costs in rats.
Article in The European journal of neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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Who cites it
61 citing papers in PubMed, 99 citations in OpenAlex.
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- Temporal dynamics of nucleus accumbens neurons in male mice during reward seeking.Nature communications · 2024Article
- Distinct Action Signals by Subregions in the Nucleus Accumbens during STOP-Change Performance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Inactivation of phosphodiesterase-4B gene in rat nucleus accumbens shell by CRISPR/Cas9 or positive allosteric modulation of the protein affects the motivation to chronically self-administer nicotine.Scientific reports · 2024Article
- Error-related signaling in nucleus accumbens D2 receptor-expressing neurons guides inhibition-based choice behavior in mice.Nature communications · 2023Article
- Prelimbic cortex neural encoding dynamically tracks expected outcome value.Physiology & behavior · 2022Article
- Prenatal dexamethasone exposure alters effort decision making and triggers nucleus accumbens and anterior cingulate cortex functional changes in male rats.Translational psychiatry · 2022Article
- Corticostriatal circuits in the transition to chronic back pain: The predictive role of reward learning.Cell reports. Medicine · 2022Article
- Distinct role of nucleus accumbens D2-MSN projections to ventral pallidum in different phases of motivated behavior.Cell reports · 2022Article
- Neuroplastic Changes in the Superior Colliculus and Hippocampus in Self-rewarding Paradigm: Importance of Visual Cues.Molecular neurobiology · 2022Article
- Regulation of dopamine-dependent transcription and cocaine action by Gadd45b.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Neurons of the Ventral Tegmental Area Encode Individual Differences in Motivational "Wanting" for Reward Cues.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Loss of nucleus accumbens low-frequency fluctuations is a signature of chronic pain.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Nucleus accumbens shell dopamine mediates outcome value, but not predicted value, in a magnitude decision-making task.The European journal of neuroscience · 2020Article
- The power of price compels you: Behavioral economic insights into dopamine-based valuation of rewarding and aversively motivated behavior.Brain research · 2019Review
- Deconstructing value-based decision making via temporally selective manipulation of neural activity: Insights from rodent models.Cognitive, affective & behavioral neuroscience · 2019Review
- Prelimbic Cortical Neurons Track Preferred Reward Value and Reflect Impulsive Choice during Delay Discounting Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Striatal action-value neurons reconsidered.eLife · 2018Article
- Coordinated Ramping of Dorsal Striatal Pathways preceding Food Approach and Consumption.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
1 more citing papers are in PubMed but not listed here.
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Abstract
Efficient decision-making requires that animals consider both the benefits and the costs of potential actions, such as the amount of effort or temporal delay involved in reward seeking. The nucleus accumbens (NAc) has been implicated in the ability to choose between options with different costs and overcome high costs when necessary, but it is not clear how NAc processing contributes to this role. Here, neuronal activity in the rat NAc was monitored using multi-neuron electrophysiology during two cost-based decision tasks in which either reward effort or reward delay was manipulated. In each task, distinct visual cues predicted high-value (low effort/immediate) and low-value (high effort/delayed) rewards. After training, animals exhibited a behavioral preference for high-value rewards, yet overcame high costs when necessary to obtain rewards. Electrophysiological analysis indicated that a subgroup of NAc neurons exhibited phasic increases in firing rate during cue presentations. In the effort-based decision task (but not the delay-based task), this population reflected the cost-discounted value of the future response. In contrast, other subgroups of cells were activated during response initiation or reward delivery, but activity did not differ on the basis of reward cost. Finally, another population of cells exhibited sustained changes in firing rate while animals completed high-effort requirements or waited for delayed rewards. These findings are consistent with previous reports that implicate NAc function in reward prediction and behavioral allocation during reward-seeking behavior, and suggest a mechanism by which NAc activity contributes to both cost-based decisions and actual cost expenditure.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.