ArticleThe European journal of neuroscience2011
Neurogranin phosphorylation fine-tunes long-term potentiation.
Article in The European journal of neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- Temporal-Specific Sex and Injury-Dependent Changes on Neurogranin-Associated Synaptic Signaling After Controlled Cortical Impact in Rats.Molecular neurobiology · 2024Article
- Genetic mechanisms for impaired synaptic plasticity in schizophrenia revealed by computational modeling.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Neurogranin-like immunoreactivity in the zebrafish brain during development.Brain structure & function · 2022Article
- Distribution of neurogranin-like immunoreactivity in the brain and sensory organs of the adult zebrafish.The Journal of comparative neurology · 2022Article
- Neurogranin Regulates Adult-Born Olfactory Granule Cell Spine Density and Odor-Reward Associative Memory in Mice.International journal of molecular sciences · 2021Article
- Calmodulin Binding Proteins and Alzheimer's Disease: Biomarkers, Regulatory Enzymes and Receptors That Are Regulated by Calmodulin.International journal of molecular sciences · 2020Review
- α-Actinin-1 promotes activity of the L-type CaThe EMBO journal · 2020Article
- Hippocampal Protein Kinase C Signaling Mediates the Short-Term Memory Impairment Induced by Delta9-Tetrahydrocannabinol.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Neurogranin regulates CaM dynamics at dendritic spines.Scientific reports · 2015Article
- Neurogranin binds α-synuclein in the human superior temporal cortex and interaction is decreased in Parkinson's disease.Brain research · 2014Article
- Post-embedding Immunogold labeling of synaptic proteins in hippocampal slice cultures.Journal of visualized experiments : JoVE · 2013Article
- Structural basis for the interaction of unstructured neuron specific substrates neuromodulin and neurogranin with Calmodulin.Scientific reports · 2013Article
- Pcp4l1 contains an auto-inhibitory element that prevents its IQ motif from binding to calmodulin.Journal of neurochemistry · 2012Article
- Pull-down of calmodulin-binding proteins.Journal of visualized experiments : JoVE · 2012Article
- Neurogranin targets calmodulin and lowers the threshold for the induction of long-term potentiation.PloS one · 2012Article
- Risk variant for schizophrenia in the neurogranin gene impacts on hippocampus activation during contextual fear conditioning.Molecular psychiatry · 2011Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Learning-related potentiation of synaptic strength at Cornu ammonis subfield 1 (CA1) hippocampal excitatory synapses is dependent on neuronal activity and the activation of glutamate receptors. However, molecular mechanisms that regulate and fine-tune the expression of long-term potentiation (LTP) are not well understood. Recently it has been indicated that neurogranin (Ng), a neuron-specific, postsynaptic protein that is phosphorylated by protein kinase C, potentiates synaptic transmission in an LTP-like manner. Here, we report that a Ng mutant that is unable to be phosphorylated cannot potentiate synaptic transmission in rat CA1 hippocampal neurons and results in a submaximal expression of LTP. Our results provide the first evidence that the phosphorylation of Ng can regulate LTP expression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.