ArticleTissue engineering. Part A2011
Sustained delivery of dibutyryl cyclic adenosine monophosphate to the transected spinal cord via oligo [(polyethylene glycol) fumarate] hydrogels.
Article in Tissue engineering. Part A, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 46 citations in OpenAlex.
- Open-Spaced Ridged Hydrogel Scaffolds Containing TiOInternational journal of molecular sciences · 2023Article
- Current Concepts of Biomaterial Scaffolds and Regenerative Therapy for Spinal Cord Injury.International journal of molecular sciences · 2023Review
- Multifaceted Roles of cAMP Signaling in the Repair Process of Spinal Cord Injury and Related Combination Treatments.Frontiers in molecular neuroscience · 2022Review
- A multi-channel collagen scaffold loaded with neural stem cells for the repair of spinal cord injury.Neural regeneration research · 2021Article
- Newly regenerated axons via scaffolds promote sub-lesional reorganization and motor recovery with epidural electrical stimulation.NPJ Regenerative medicine · 2021Article
- Article
- Promoting Neuronal Outgrowth Using Ridged Scaffolds Coated with Extracellular Matrix Proteins.Biomedicines · 2021Article
- Hydrogel-based local drug delivery strategies for spinal cord repair.Neural regeneration research · 2021Review
- Recent advances in nanotherapeutic strategies for spinal cord injury repair.Advanced drug delivery reviews · 2019Review
- GDNF Schwann cells in hydrogel scaffolds promote regional axon regeneration, remyelination and functional improvement after spinal cord transection in rats.Journal of tissue engineering and regenerative medicine · 2018Article
- Biomaterial Scaffolds in Regenerative Therapy of the Central Nervous System.BioMed research international · 2018Review
- Microsphere-Based Scaffolds in Regenerative Engineering.Annual review of biomedical engineering · 2017Review
- Biomaterials for Local, Controlled Drug Delivery to the Injured Spinal Cord.Frontiers in pharmacology · 2017Review
- Positively Charged Oligo[Poly(Ethylene Glycol) Fumarate] Scaffold Implantation Results in a Permissive Lesion Environment after Spinal Cord Injury in Rat.Tissue engineering. Part A · 2015Article
- Adenosine-associated delivery systems.Journal of drug targeting · 2015Review
- Comparison of cellular architecture, axonal growth, and blood vessel formation through cell-loaded polymer scaffolds in the transected rat spinal cord.Tissue engineering. Part A · 2014Article
- Implantation of cauda equina nerve roots through a biodegradable scaffold at the conus medullaris in rat.The spine journal : official journal of the North American Spine Society · 2014Article
- Repair of injured spinal cord using biomaterial scaffolds and stem cells.Stem cell research & therapy · 2014Review
- Hemisection spinal cord injury in rat: the value of intraoperative somatosensory evoked potential monitoring.Journal of neuroscience methods · 2012Article
- Combination therapies in the CNS: engineering the environment.Neuroscience letters · 2012Review
Corrections and comments
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Authors and funding
11 authors at 1 institution in 2 countries.
Funding
Abstract
This study describes the use of oligo [(polyethylene glycol) fumarate] (OPF) hydrogel scaffolds as vehicles for sustained delivery of dibutyryl cyclic adenosine monophosphate (dbcAMP) to the transected spinal cord. dbcAMP was encapsulated in poly(lactic-co-glycolic acid) (PLGA) microspheres, which were embedded within the scaffolds architecture. Functionality of the released dbcAMP was assessed using neurite outgrowth assays in PC12 cells and by delivery to the transected spinal cord within OPF seven channel scaffolds, which had been loaded with Schwann cells or mesenchymal stem cells (MSCs). Our results showed that encapsulation of dbcAMP in microspheres lead to prolonged release and continued functionality in vitro. These microspheres were then successfully incorporated into OPF scaffolds and implanted in the transected thoracic spinal cord. Sustained delivery of dbcAMP inhibited axonal regeneration in the presence of Schwann cells but rescued MSC-induced inhibition of axonal regeneration. dbcAMP was also shown to reduce capillary formation in the presence of MSCs, which was coupled with significant functional improvements. Our findings demonstrate the feasibility of incorporating PLGA microsphere technology for spinal cord transection studies. It represents a novel sustained delivery mechanism within the transected spinal cord and provides a platform for potential delivery of other therapeutic agents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.