Evidence map›Paper›PMID 21197660›Full record

ReviewWiley interdisciplinary reviews. Systems biology and medicine

Adaptation of cells to new environments.

Aaron N Brooks, Serdar Turkarslan, Karlyn D Beer, Fang Yin Lo, Nitin S Baliga

Abstract readReview
In one paragraph

Review in Wiley interdisciplinary reviews. Systems biology and medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.

0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

82 citing papers in PubMed.

  1. Review
  2. Role of mEpigenomes · 2025
    Review
  3. Article
  4. Article
  5. A rapid review of the avian influenza PB2 E627K mutation in human infection studies.Canada communicable disease report = Releve des maladies transmissibles au Canada · 2025
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Short-term artificial adaptation ofFrontiers in plant science · 2024
    Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Review

22 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Aaron N BrooksMolecular and Cellular Biology Program, University of Washington, Seattle, WA, USA.
Serdar Turkarslan
Karlyn D Beer
Fang Yin Lo
Nitin S Baliga

Funding

Quantitative Systems BiologyP50GM076547 · NIGMS · INSTITUTE FOR SYSTEMS BIOLOGY · PI BALIGA, NITIN S · 2006 to 2016
$30.6M
Interrogation of systems level mechanisms controlling DNA repair processesR01GM077398 · NIGMS · INSTITUTE FOR SYSTEMS BIOLOGY · PI BALIGA, NITIN S · 2007 to 2010
$1.3M
NIGMS NIH HHS 1R01GM077398-01A2NIGMS NIH HHS P50 GM076547NIGMS NIH HHS P50GM076547NIGMS NIH HHS R01 GM077398
6 · The paper itself

Abstract

The evolutionary success of an organism is a testament to its inherent capacity to keep pace with environmental conditions that change over short and long periods. Mechanisms underlying adaptive processes are being investigated with renewed interest and excitement. This revival is partly fueled by powerful technologies that can probe molecular phenomena at a systems scale. Such studies provide spectacular insight into the mechanisms of adaptation, including rewiring of regulatory networks via natural selection of horizontal gene transfers, gene duplication, deletion, readjustment of kinetic parameters, and myriad other genetic reorganizational events. Here, we discuss advances in prokaryotic systems biology from the perspective of evolutionary principles that have shaped regulatory networks for dynamic adaptation to environmental change.

Indexed as

Adaptation, PhysiologicalEnvironmental MicrobiologyEvolution, MolecularGene Regulatory NetworksGenomicsProkaryotic Cells

Identifiers

PMID21197660
PMCPMC3081528

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.